- A Cd(ii) and Zn(ii) selective naphthyl based [2]rotaxane acts as an exclusive Zn(ii) sensor upon further functionalization with pyrene
-
A new multi-functional [2]rotaxane, ROTX, has been synthesized via a Cu(i) catalysed azide-alkyne cycloaddition reaction between Ni(ii) templated azide terminated pseudorotaxane composed of a naphthalene based heteroditopic wheel, NaphMC, and an alkyne terminated stopper. Subsequently, ROTX has been functionalized with pyrene moieties to develop a bifluorophoric [2]rotaxane, PYROTX, having naphthalene and pyrene moieties. Detailed characterization of these two rotaxanes is performed by utilizing several techniques such as ESI-MS, (1D and 2D) NMR, UV/Vis and PL studies. Comparative metal ion sensing studies of NaphMC (a fluorophoric cyclic receptor), ROTX ([2]rotaxane with a naphthyl fluorophore) and PYROTX ([2]rotaxane having naphthyl and pyrene fluorophores) have been performed to determine the effect of dimensionality/functionalization on the metal ion selectivity. Although NaphMC fails to discriminate between metal ions, ROTX serves as a selective sensor for Zn(ii) and Cd(ii). Importantly, PYROTX shows exclusive selectivity towards Zn(ii) over various transition, alkali and alkaline earth metal ions including Cd(ii).
- Bej, Somnath,Nandi, Mandira,Ghosh, Pradyut
-
supporting information
p. 294 - 303
(2021/01/11)
-
- Metal-free C-H functionalization of pyrrolidine to pyrrolinium-based room temperature ionic liquid crystals
-
The development of ionic liquid crystals (ILCs) using pyrrolidinium cation has received considerable interest due to their higher electrochemical stability. However, high charge density associated with low charge distribution in the fully saturated pyrrol
- Mandal, Sumana,Gupta, Ravindra Kumar,Pathak, Suraj Kumar,Rao, D. S. Shankar,Prasad, S. Krishna,Ammathnadu Sudhakar, Achalkumar,Jana, Chandan K.
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supporting information
p. 8064 - 8071
(2021/05/21)
-
- Optical "blinking" Triggered by Collisions of Single Supramolecular Assemblies of Amphiphilic Molecules with Interfaces of Liquid Crystals
-
We report that incubation of aqueous dispersions of supramolecular assemblies formed by synthetic alkyl triazole-based amphiphiles against interfaces of thermotropic liquid crystals (LCs; 4-cyano-4′-pentylbiphenyl) triggers spatially localized (micrometer
- Abbott, Nicholas L.,Kim, Young-Ki,Shivrayan, Manisha,Thayumanavan, S.,Tsuei, Michael
-
supporting information
p. 6139 - 6148
(2020/04/27)
-
- Rational Design of Supramolecular Dynamic Protein Assemblies by Using a Micelle-Assisted Activity-Based Protein-Labeling Technology
-
The self-assembly of proteins into higher-order superstructures is ubiquitous in biological systems. Genetic methods comprising both computational and rational design strategies are emerging as powerful methods for the design of synthetic protein complexes with high accuracy and fidelity. Although useful, most of the reported protein complexes lack a dynamic behavior, which may limit their potential applications. On the contrary, protein engineering by using chemical strategies offers excellent possibilities for the design of protein complexes with stimuli-responsive functions and adaptive behavior. However, designs based on chemical strategies are not accurate and therefore, yield polydisperse samples that are difficult to characterize. Here, we describe simple design principles for the construction of protein complexes through a supramolecular chemical strategy. A micelle-assisted activity-based protein-labeling technology has been developed to synthesize libraries of facially amphiphilic synthetic proteins, which self-assemble to form protein complexes through hydrophobic interaction. The proposed methodology is amenable for the synthesis of protein complex libraries with molecular weights and dimensions comparable to naturally occurring protein cages. The designed protein complexes display a rich structural diversity, oligomeric states, sizes, and surface charges that can be engineered through the macromolecular design. The broad utility of this method is demonstrated by the design of most sophisticated stimuli-responsive systems that can be programmed to assemble/disassemble in a reversible/irreversible fashion by using the pH or light as trigger.
- Sandanaraj, Britto S.,Reddy, Mullapudi Mohan,Bhandari, Pavankumar Janardhan,Kumar, Sugam,Aswal, Vinod K.
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supporting information
p. 16085 - 16096
(2018/10/15)
-
- Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters
-
An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.
- Hoque, Md Emdadul,Bisht, Ranjana,Haldar, Chabush,Chattopadhyay, Buddhadeb
-
supporting information
p. 7745 - 7748
(2017/06/21)
-
- Synthesis of Water-Dispersible Pd Nanoparticles Using a Novel Oxacalixarene Derivative and their Catalytic Application in C–C Coupling Reactions
-
A novel 5,17-di(hydrazinecarbonyl) tetranitrooxacalix[4]arene (DHOC) derivative has been synthesized and characterized using various spectroscopic techniques. This DHOC derivative has been used to produce water-dispersible catalytically active Pd nanoparticles (PdNps). In the nanoparticle synthesis, DHOC serves as both a reducing and a stabilizing agent, thus simplifying the preparation of the PdNps because no separate reagents are required to reduce and stabilize the nanoparticles. These PdNps were characterized by a number of techniques such as Transmission Electron Microscopy and UV–Visible spectroscopy. The water-dispersible PdNps were 5?±?2?nm in size and showed high catalytic activity in numerous C–C coupling reactions such as the Sonogashira, Suzuki-Miyuara and Heck reactions. Graphical Abstract: [Figure not available: see fulltext.]
- Mehta, Viren,Panchal, Manthan,Kongor, Anita,Panchal, Urvi,Jain
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p. 1581 - 1590
(2016/07/29)
-
- Columnar liquid crystalline self-assembly of hydrogen-bonded rod-coil diblock complexes created from pyrazole/benzoic acid derivatives
-
We synthesized hydrogen-bonded rod-coil diblock complexes having both a rigid rod and a flexible coil by combining bithiophene-conjugated pyrazole derivatives and alkoxy-substituted benzoic acid derivatives. Their self-assembled nanostructures were investigated using polarized optical microscopy, molecular modeling, and X-ray scattering in liquid crystalline (LC) state. They form different types of supramolecularLCphases depending on the numbers and lengths of alkoxy substituents in the benzoic acids. Diblock complexes with low volume ratios of aliphatic coils to rod segments (dioctyloxy chains) self-assembled into lamellar phases; systems with higher ratios (didodecyloxy, trioctyloxy, and tridodecyloxy chains) formed columns. In these columnar structures, two pyrazoles and two benzoic acids formed an aromatic tetramer core through N-H···O and O-H···N hydrogen bonds. Two sets of aromatic tetramers surrounded by flexible aliphatic chains were then stacked to give columnar phases. These are novel examples of supramolecular LC structures comprising hydrogen-bonded pyrazole-benzoic acid derivatives with tetrameric rigid aromatic scaffolds.
- Kim, Ho-Joong,Cho, Sung,Park, Jung Su
-
p. 2740 - 2745
(2015/11/17)
-
- Size-regulable vesicles based on anion-π interactions
-
Taking tetraoxacalix[2]arene[2]triazine as a functionalization platform, a series of new amphiphilic molecules were synthesized in 18 to 53% yields by using a fragment coupling protocol. These amphiphilic molecules self-assembled into stable vesicles in a
- He, Qing,Han, Yuchun,Wang, Yilin,Huang, Zhi-Tang,Wang, De-Xian
-
supporting information
p. 7486 - 7491
(2014/06/23)
-
- Syntheses, structures, and luminescence properties of four metal-organic polymers with undocumented topologies constructed from 3,5-bis((4′- carboxylbenzyl)oxy)benzoate ligand
-
Solvothermal reactions of one semirigid tricarboxylic acid and transition metal cations in the absence or presence of 1,4-bis(1H-imidazol-4-yl)benzene (1,4-bib) afford four coordination polymers, namely, [Cd(Hbcb)]n (1), and [M(Hbcb)(1,4-bib)]
- Zhang, Xiutang,Fan, Liming,Song, Weikuo,Fan, Weiliu,Sun, Liming,Zhao, Xian
-
p. 30274 - 30281
(2014/08/05)
-
- Rotaxane with multiple functional groups
-
High-yield syntheses of Cu(II)- and Ni(II)-templated [2]pseudorotaxane precursors (CuPRT and NiPRT, respectively) were achieved by threading bis(azide)bis(amide)-2,2-bipyridine axle into a bis(amide)tris(amine) macrocycle. Single-crystal X-ray structural analysis of CuPRT revealed complete threading of the axle fragment into the wheel cavity, where strong aromatic π-π stacking interactions between two parallel arene moieties of the wheel and the pyridyl unit of axle are operative in addition to metal ion templation. Attachment of a newly developed bulky stopper molecule with a terminal alkyne to CuPRT via a Cu(I)-catalyzed azide-alkyne cycloaddition reaction failed as a result of dethreading of the azide-terminated axle under the reaction conditions. However, the synthesis of a metal-free [2]rotaxane containing triazole with other functionalities in the axle was achieved in ~45% yield upon coupling between azide-terminated NiPRT and the alkyne-terminated stopper. The [2]rotaxane was characterized by mass spectrometry, 1D and 2D NMR (COSY, DOSY, and ROESY) experiments. Comparative solution-state NMR studies of the [2]rotaxane in its unprotonated and protonated states were carried out to locate the position of the wheel on the axle of the metal-free [2]rotaxane. Furthermore, a variable-temperature 1H NMR study in DMSO-d6 of [2]rotaxane supported the kinetic inertness of the interlocked structure, where the newly developed stopper prevents dethreading of the 30-membered wheel from the axle.
- Saha, Subrata,Santra, Saikat,Akhuli, Bidyut,Ghosh, Pradyut
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p. 11170 - 11178
(2015/02/19)
-
- Organopalladium complexes of oxacalixarenes: Selecting the lid for the three-dimensional scaffold
-
The first organometallic (palladium) complexes of oxacalixarene molecules were prepared via oxidative addition of the C-I bond at the lower rim. The unique geometry of the oxacalixarene scaffold allowed for the selective introduction of new ligands at the
- Visitaev, Yulia,Goldberg, Israel,Vigalok, Arkadi
-
supporting information
p. 6779 - 6781
(2013/07/25)
-
- Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV
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Using hydroxy-/dihydroxybenzoic acids as leads, a series of methyl, ethyl and iso-propyl esters of 4-hydroxy-benzoic acid, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5-dihydroxybenzoic acids and of coumaric acid, were obtained and investigated for the inhibition of six mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms, that is, the cytosolic CA I, II and VII, and the transmembrane CA IX, XII and XIV, many of which are established drug targets. Other compounds incorporating phenol/catechol moieties were obtained from dopamine by reaction with fluorescein isothiocyanate or with 2,4,6-trisubstituted pyrylium salts. Some aminophenols were also derivatized in a similar manner, by using pyrylium salts. Many of these compounds showed increased inhibitory action compared to the lead compounds from which they were obtained, with efficacy in the submicromolar range against most investigated CA isoforms. As phenols are a class of less investigated CA inhibitors (CAIs) compared to the sulfonamides, and their mechanism of inhibition is less well understood, compounds of the type designed here may be helpful in gaining more insights into these phenomena.
- Carta, Fabrizio,Vullo, Daniela,Maresca, Alfonso,Scozzafava, Andrea,Supuran, Claudiu T.
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supporting information
p. 1564 - 1569
(2013/04/10)
-
- TREATMENT OF DISEASES BY EPIGENETIC REGULATION
-
The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.
- -
-
Paragraph 0439; 0440
(2013/11/05)
-
- Flavone-based novel antidiabetic and antidyslipidemic agents
-
The hybrid congeners 62-90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats and db/db mice. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared, and their antidiabetic activity results indicate its association mainly with S isomers. These compounds also lower cholesterol and TG profiles while improving high-density lipoprotein cholesterol to CHOL ratio in db/db mice. The bioavailability of compound 70 and its isomer varies between 27 and 29% whereas that of the more polar compound 90a is poor as determined in rat by oral and intraperitoneal administrations. Published 2012 by the American Chemical Society.
- Verma, Alok K.,Singh, Himanshu,Satyanarayana, Mavurapu,Srivastava, Swayam P.,Tiwari, Priti,Singh, Amar B.,Dwivedi, Anil K.,Singh, Shio K.,Srivastava, Mukesh,Nath, Chandishwar,Raghubir, Ram,Srivastava, Arvind K.,Pratap, Ram
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supporting information; experimental part
p. 4551 - 4567
(2012/07/30)
-
- Practical preparation of resveratrol 3-O-β-D-glucuronide
-
A practical synthesis of resveratrol 3-Oβl-D-glucuronide, suitable for preparation of large quantities, was developed using selective deacetylation of resveratrol triacetate with ammonium acetate. A simplified procedure for large-scale preparation of resveratrol is also reported.
- Jungong, Christian S.,Novikov, Alexei V.
-
p. 3589 - 3597,9
(2020/08/31)
-
- Temperature sensitivity trends and multi-stimuli sensitive behavior in amphiphilic oligomers
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A series of oligomers, containing oligo(ethylene glycol) (OEG) moieties, with the same composition of amphiphilic functionalities has been designed, synthesized, and characterized on the basis of their temperature-sensitive behavior. The non-covalent amph
- Wang, Feng,Klaikherd, Akamol,Thayumanavan
-
scheme or table
p. 13496 - 13503
(2011/10/09)
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- NOVEL ANTI-INFLAMMATORY AGENTS
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Disclosed are methods of regulating interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1) and methods of treating and/or preventing cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s) by administering a naturally occurring or synthetic quinazolone derivative. The invention provides novel synthetic quinazolone compounds, as well as pharmaceutical compositions comprising those compounds.
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Page/Page column 78-80
(2010/11/05)
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- Synthesis of organometallic poly(dendrimer)s by macromonomer polymerization: effect of dendrimer size and structural rigidity on the polymerization efficiency
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Two series of first to third generation (G1-G3) oligoether dendrimers, one hearing a shorter spacer chain (C-O) and the other having a longer spacer branch (C-C-C-O) were prepared. Both series of compounds, containing two reactive C≡CH moieties on the dendrimer surface, were used as macromonomers and copolymerized with trans-[Pt(PEt3)2Cl2] to form organometallic poly(dendrimer)s by an outer-sphere-outer-sphere connection strategy. It was found that concentration of monomer used in the polymerization, the dendrimer generation, and, most strikingly, the length of the spacer were key factors that determined the polymerization efficiency. Hence, the structurally more rigid and compact C-O linked dendrimers formed poly(dendrimer)s with a higher degree of polymerization than the structurally less rigid and more bulky C-C-C-O dendrimers. This result was due to the higher tendency to form cyclic oligomers in the latter series of compounds. In addition, the differences in the polymerization efficiency among the three generations of dendrimers could be explained by the gradual decrease of reactive functional group density on the dendrimer surface.
- Cheung, Siu-Yin,Chow, Hak-Fun,Ngai, To,Wei, Xiaoling
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supporting information; experimental part
p. 2278 - 2288
(2009/10/23)
-
- A Simple, efficient, green, cost effective and chemoselective process for the esterification of carboxylic acids
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Carboxylic acids have been esterified under mild and solvent-free conditions in high yield and purity using the green reagents, dimethyl carbonate and diethyl carbonate, under acid catalysis. The present methodology is free of the disadvantages of base catalysis described earlier, such as high temperatures, use of autoclaves, use of the expensive DBU as base in stoichiometric amounts and the carbonate as solvent. High chemoselectivity is observed in the case of hydroxybenzoic acids.
- Rekha,Ramani, Modukuri V.,Ratnamala,Rupakalpana, Vempati,Subbaraju, Gottumukkala V.,Satyanarayana, Chava,Rao, C. Someswara
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experimental part
p. 769 - 773
(2010/04/22)
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- Chemoselective esterification of phenolic acids in the presence of sodium bicarbonate in ionic liquids
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Chemoselective esterification of phenolic acids with dialkyl sulphates or alkyl halides in the presence of sodium bicarbonate in 1,3-dialkylimidazolium ionic liquids is reported in excellent yields and less reaction time as compared to organic solvents. Copyright Taylor & Francis Group, LLC.
- Ambika,Singh, Pradeep Pratap,Chauhan
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p. 928 - 936
(2008/09/17)
-
- Synthesis and structure of upper-rim 1,3-alternate tetraoxacalix[2]arene[2] triazine azacrowns and change of cavity in response to fluoride anion
-
(Chemical Equation Presented) The upper-rim 1,3-alternate tetraoxacalix[2]arene[2]triazine azacrowns were constructed effectively by macrocyclic condensation reaction of diamines with dichlorinated tetraoxacalix[2]arene[2]triazine intermediates that were
- Hou, Bao-Yong,Wang, De-Xian,Yang, Hai-Bo,Zheng, Qi-Yu,Wang, Mei-Xiang
-
p. 5218 - 5226
(2008/02/09)
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- En route to inherently chiral tetraoxacalix[2]arene[2]triazines
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This paper describes our attempts to synthesize inherently chiral heteroatom-bridged calixaromatics. Based on a stepwise fragment-coupling approach using a chiral 3,5-dihydroxybenzamide or benzoate, 2,4-dihydroxyacetophenone, and cyanuric chloride as reac
- Hou, Bao-Yong,Zheng, Qi-Yu,Wang, De-Xian,Wang, Mei-Xiang
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p. 10801 - 10808
(2008/02/13)
-
- Invertible amphiphilic polymers
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Amphiphilic monomeric compounds and corresponding homopolymers and copolymers capable of assembly and invertible configuration in introduction to and change in fluid medium.
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Page/Page column 6; 7
(2010/11/29)
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- OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS
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The present invention provides novel substituted flavone derivatives which exhibit anti- hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type ii diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.
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Page/Page column 14
(2010/11/08)
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- Initial investigation into the Suzuki-Miyaura vinylation of hindered aryl bromides utilizing potassium vinyltrifluoroborate
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An initial study of the Suzuki-Miyaura cross-coupling of potassium vinyltrifluoroborate (2) and hindered aryl bromides is presented. Coupling of benzyl 3,5-bis(benzyloxy)-4-bromobenzoate (1) leads to a mixture of the desired styrene derivative, and the reduced product.
- Carter, Rhiannon R.,Wyatt, Justin K.
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p. 6091 - 6094
(2007/10/03)
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- 3-PHENYL-CINNOLINE HOMOLOGUE AND ANTITUMOR AGENT CONTAINING THE SAME
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The present invention relates to a 3-phenyl-cinnoline analogue or a physiologically acceptable salt thereof, and a cell proliferation inhibitor and an antitumor agent comprising the same, as an active ingredient.
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Page/Page column 26
(2008/06/13)
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- Synthesis of a tetrasubstituted arylphosphonate via the anionic phospho-Fries rearrangement
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The anionic phospho-Fries rearrangement of phosphoric acid (3,5-di-isopropoxy)phenyl ester diethyl ester (11) gave rise to (2-hydroxy-4,6-di-isopropoxy-phenyl)phosphonic acid diethyl ester (12) in excellent yield. The phenol functionality of 12 was converted to the corresponding triflate which was coupled with vinyltributylstannane, under Stille conditions, to give a styrene. This molecule is intended to serve as the aromatic fragment in the synthesis of a phosphorus-based transition-state analogue for the hydrolysis of the S-(-)-zearalenone lactone.
- Jayasundera, Krishanthi P.,Watson, Amy J.,Taylor, Carol M.
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p. 4311 - 4313
(2007/10/03)
-
- Homopolymer micelles in heterogeneous solvent mixtures
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Amphiphilic homopolymers containing a hydrophilic and a hydrophobic functionality in each monomer unit have been shown to form polar or apolar containers depending on the solvent environment. When presented with a mixture of solvents, these polymeric cont
- Basu, Subhadeep,Vutukuri, Dharma Rao,Thayumanavan
-
p. 16794 - 16795
(2007/10/03)
-
- Invertible amphiphilic homopolymers
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Stimuli-responsive polymers and assemblies are viable candidates for the so-called "smart" materials. In this communication, we report a new class of amphiphilic homopolymers that forms micelle-like structures in polar solvents and inverted micelle-like structures in apolar solvents. We demonstrate that these superstructures are the result of the changes in the molecular-level conformations in the monomer. Copyright
- Basu, Subhadeep,Vutukuri, Dharma Rao,Shyamroy, Subarana,Sandanaraj, Britto S.,Thayumanavan
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p. 9890 - 9891
(2007/10/03)
-
- Synthesis of new unsymmetrical polyarylester dendrimers
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Preparation of polyarylester dendrimers containing 2-(hydroxymethyl)-1,4- butanediol and 2,2-bis(hydroxymethyl)-1,4-butanediol cores is described. These polyarylester dendrimers are unsymmetrical with respect to chain lengths and function as model systems for studying in vitro controlled drug release systems. Reaction conditions for deprotection of trichloroethyl group of the dendritic wedges have been improved.
- Potluri, Srinagesh Kumar,Ramulu, A. Raghu,Pardhasaradhi
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p. 3739 - 3744
(2007/10/03)
-
- A mild deprotection strategy for allyl-protecting groups and its implications in sequence specific dendrimer synthesis
-
A mild deprotection strategy for allyl ethers under basic conditions in the presence of a palladium catalyst is described. Under these conditions, aryl allyl ethers can be cleaved selectively in the presence of alkyl allyl ethers. These conditions are also effective in the deprotection of allyloxycarbonyl groups. The utility of the current methodology in sequence specific dendrimer synthesis is demonstrated.
- Vutukuri, Dharma Rao,Bharathi, Pandi,Yu, Zhouying,Rajasekaran, Karthik,Tran, My-Huyen,Thayumanavan
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p. 1146 - 1149
(2007/10/03)
-
- Functional group diversity in dendrimers
-
(graph presented) A methodology for synthesizing dendrons with different peripheral functionalities is described. The benzyl ether-based dendrons reported here were synthesized using allyl and methoxymethyl ether-based protection-deprotection strategies.
- Sivanandan, Kulandaivelu,Vutukuri, Dharmarao,Thayumanavan
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p. 3751 - 3753
(2007/10/03)
-
- Novel chemoselective de-esterification of esters of polyacetoxy aromatic acids by lipases
-
Candida cylindracea lipase (CCL) and porcine pancreatic lipase (PPL) have been used for deacetylation of peracetates of methyl and ethyl esters of six different polyphenolic acids in organic solvents. Exclusive de-esterification of the ester groups derived from the phenolic hydroxy and aliphatic acid over the ester group of the aromatic acid and aliphatic alcohol has been achieved affording the corresponding esters of phenolic acids in as high yields as 90-97%. The results have been corroborated with the mechanism of lipase action.
- Parmar, Virinder S.,Kumar, Ajay,Bicht, Kirpal S.,Mukherjee, Shubhasish,Prasad, Ashok K.,Sharma, Sunil K.,Wengel, Jesper,Olsen, Carl E.
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p. 2163 - 2176
(2007/10/03)
-
- Synthesis, structure and complexation properties of a functionalised calixcrown-6 ligand, the 1,3-alternate form of calix[4]arene-1,3;2,4-bis-[(5-ethoxycarbonyl-1,3-phenylene)crown-6]
-
The synthesis and structural characterisation of a new calix[4]areneMscrown-6 ligand. C62H68O16, in which 1.3-phenylene units form spacer groups within the polyether chains, are described. Crystallised from chloroform/hexa
- Abidi, Rym,Asfari, Zouhair,Harrowfield, Jack M.,Nauman, Christoph,Sobolev, Alexander N.,Vicens, Jacques
-
-
- Synthesis, Liquid Crystals and Photochemistry of Di- and Tristyrylbenzenes with Alkoxy Side Chains
-
The all-(E)-configurated distyrylbenzenes 4a-g and 1,3,5-tristyrylbenzenes 6a,b,g were prepared by stereoselective condensation reactions of azomethines 2 and methylarenes 3 and 4, respectively. 4a,b,d and e generate light sensitive liquid crystals due to
- Zerban, Georg,Meier, Herbert
-
p. 171 - 184
(2007/10/02)
-
- Orally active bronchospasmolytic compounds and their preparation
-
Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: EQU1 wherein R1 is a member of the class consisting of tertiary butyl and cyclobutyl, and R2 is a hydrogen or 2 to 5 carbon atom acyl radical, and pharmaceutically acceptable salts thereof. The activity of these compounds is compared to previously known bronchodilators such as 1-(3', 5'-dihydroxyphenyl)-2-(isopropylamino)-ethanol, having the common name orciprenaline, and 1-(3', 4'-dihydroxyphenyl-2-isoproplyamino-ethanol, having the common name isoprenaline.
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