- Eco-friendly syntheses of 2-substituted benzoxazoles and 2-substituted benzothiazoles from 2-aminophenols, 2-aminothiophenols and DMF derivatives in the presence of imidazolium chloride
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A simple, economical and metal-free approach to the synthesis of 2-substituted benzoxazoles and 2-substituted benzothiazoles from 2-aminophenols, 2-aminothiophenols and DMF derivatives, only using imidazolium chloride (50% mmol) as promoter without any other additive, was reported. Various 2-substituted benzoxazoles and 2-substituted benzothiazoles were thus prepared in moderate to excellent yields.
- Tian, Qingqiang,Luo, Wen,Gan, Zongjie,Li, Dan,Dai, Zeshu,Wang, Huajun,Wang, Xuetong,Yuan, Jianyong
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supporting information
(2019/01/21)
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- Synthesis method of 2-substituted benzoxazole, 2-substituted benzothiazole and derivatives thereof
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The invention provides a synthesis method of 2-substituted benzoxazole, 2-substituted benzothiazole and derivatives thereof. In the method, through ortho-aminophenol/2-aminothiophenol cyclization catalyzed by imidazole hydrochloride, synthesis of functionalized 2-substituted benzoxazole and 2-substituted benzothiazole is realized; the method is simple, economical and high in practicality. No othercatalysts or additives are used, the synthesis method ensures good functional group tolerance and excellent yield and purity, the reaction time is short, no harsh reaction conditions are needed, andthe method is suitable for industrial production.
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Paragraph 0047; 0052-0053
(2019/02/10)
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- Efficient CDI/CH3SO3H-catalyzed, microwave-assisted synthesis of 2-substituted benzothiazoles
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CDI combined with CH3SO3H was found to be highly effective for the cyclization of 2-aminothiophenol derivatives with carboxylic acids under MW condition. Fourteen benzothiazole derivatives were synthesized in good yield and their structures were characterized by1H-NMR,13C-NMR, IR and mass spectrometry. This simple, rapid synthetic method is believed to provide a useful process for the synthesis of 2-substituted benzothiazole compounds.
- Li, Yao-Wei,Zhang, Pei-Ming,Li, Rui,Bai, Yan,Yu, Yu,Gan, Zong-Jie
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supporting information
p. 34 - 39
(2019/05/04)
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- Condensation of thioamides with 2-aminothiophenols: A versatile synthesis of benzothiazoles
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Thioamides condense with 2-aminothiophenols under convenient and mild conditions to provide a variety of simple and functionalized benzothiazoles in fair to good yields.
- Nivalkar, Kishor R.,Mashraqui, Sabir H.
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p. 3535 - 3542
(2007/10/03)
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