- Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides
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On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H37Rv in BACTEC 12B medium, using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, all those with disubstituted amide structure accompanied by one or two heteroatom(s) with loan pair(s) of electrons atom(s) β to the amide nitrogen demonstrated moderate anti-tuberculosis activity and all the monosubstituted amides showed no activity at all.
- Daryaee, Fereidoon,Kobarfard, Farzad,Khalaj, Ali,Farnia, Parisa
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experimental part
p. 289 - 295
(2009/04/07)
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- A novel method for the synthesis of 2,2-dimethyl-1,3-dioxolan-4-one, and its reactions with secondary amines
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A novel method for the synthesis of 2,2-dimethyl-1,3-dioxolan-4-one, as well as the syntheses of amides of glycolic acid via its reaction with secondary amines, is described. Georg Thieme Verlag Stuttgart.
- Boyko, Vyacheslav I.,Rodik, Roman V.,Severenchuk, Inna N.,Voitenko, Zoya V.,Kalchenko, Vitaly I.
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p. 2095 - 2096
(2008/02/12)
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- Acyloxy-1,2,4-trioxolanes by Dry Ozonolyses of Vinylesters on Polyethylene
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By dry ozonolyses on polyethylene, the vinylic esters 5a-5e afforded the corresponding ozonides 8a-8e, while 5f gave ozonide 8e.Ozonide 8a gave among other products 16 and 17 by thermal decomposition, and 21 by decomposition on silica gel. - Key Words: Acyloxy-1,2,4-trioxolanes / Ozonolysis, dry / Polyethylene / Vinylic esters
- Griesbaum, Karl,Volpp, Willi,Huh, Tae-Seong,Jung, In Chan
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p. 941 - 944
(2007/10/02)
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- Ozonolysis of Tetrasubstituted Ethylenes, Cycloolefins, and Conjugated Dienes on Polyethylene
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Ozonolyses of four tetrasubstituted ethylenes (7a-d), of two medium-sized cycloolefins (10a,b), and of norbornene (14) on polyethylene gave the corresponding ozonides, which could not be obtained by ozonolyses in solution.Ozonolyses of three conjugated dienes (25a,b,28) on polyethylene gave the corresponding diozonides, as the first examples of this class of ozonides.The thermal decomposition of some of the ozonides has been studied.
- Griesbaum, Karl,Volpp, Willi,Greinert, Reinhard,Greunig, Hans-Joachim,Schmid, Jurgen,Henke, Henning
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p. 383 - 389
(2007/10/02)
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- PHOTOLYSIS OF 5-DIAZO-2,2-DIMETHYL-4,6-DIOXO-1,3-DIOXANE (DIAZOISOPROPYLIDENEMALONIC ACID)
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The principal pathway in the photochemical (λ > 210 nm) transformation of 5-diazo-2,2-dimethyl-4,6-dioxo-1,3-dioxane in an aqueous medium (or in methanol) is splitting out of nitrogen and the Wolff rearrangement to give the stable 2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylic acid (or its methyl ester), which undergoes decarboxylation only at temperature above 150 deg C, whereas it undergoes hydrolysis to a hydroxymalonic acid in the presence of trifluoroacetic acid.
- Nikolaev, V. A.,Khimich, N. N.,Korobitsyna, I. K.
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p. 264 - 268
(2007/10/02)
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