Synthesis of (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers: Probes for the pyridoxal phosphate-dependent threonine synthase reaction
A short efficient synthesis of the threonine synthase substrate (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers is described. The synthetic route also provides access to (2S)-homoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers in high yield. Preliminary deuterium isotope effect determinations performed using the deuteriated (2S)-O-phosphohomoserines and threonine synthase from E. coli indicate that the removal of protons from both C-2 and C-3 is kinetically important.
Barclay, Fiona,Chrystal, Ewan,Gani, David
p. 683 - 689
(2007/10/03)
Synthesis of L-O-Phosphohomoserine and its C-3 Chirally Deuteriated Isotopomers: Probes for the Pyridoxal Phosphate Dependent Threonine Synthase Reaction
A short efficient synthesis of the threonine synthase substrate L-O-phosphohomoserine and its C-3 chirally deuteriated isotopomers is described; the route also provides access to L-homoserine and its C-3 chirally deuteriated isotopomers in high yield.
Barclay, Fiona,Chrystal, Ewan,Gani, David
p. 815 - 816
(2007/10/02)
Improved synthesis of o-phosphohomoserine.
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Schnyder,Rottenberg
p. 518 - 521
(2007/10/05)
A synthesis of homoserine phosphate and a blocked derivative suitable for peptide synthesis.
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Fickel,Gilvarg
p. 1421 - 1423
(2007/10/06)
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