A practical synthesis of aryl tetrafluoroethyl ethers via the improved reaction of phenols with 1,2-dibromotetrafluoroethane
An efficient and practical synthesis of various aryl tetrafluoroethyl ethers by the reaction of phenols with 1,2-dibromotetrafluoroethane and the subsequent reduction with zinc dust was described. The nucleophilic substitution of 1,2-dibromotetrafluoroethane with phenols initiated by bromophilic attack was improved by using Cs2CO3 as a base and DMSO as a solvent.
Li, Jianqing,Qiao, Jennifer X.,Smith, Daniel,Chen, Bang-Chi,Salvati, Mark E.,Roberge, Jacques Y.,Balasubramanian, Balu N.
p. 7516 - 7519
(2008/03/14)
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