- Photocatalytic Neophyl Rearrangement and Reduction of Distal Carbon Radicals by Iminyl Radical-Mediated C?C Bond Cleavage
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The control of selectivity in the reactions of the highly reactive open-shell carbon radicals is an attractive but often challenging task. Building on the strategy of photoinduced iminyl radical-mediated C?C bond cleavage, we have developed photocatalytic neophyl rearrangement and reduction of distal carbon radicals under visible light irradiation of O-acyl oximes. This mild protocol tolerates a wide range of readily available O-acyl oximes, enabling facile synthesis of diversely substituted α,β-unsaturated nitriles and β-functionalized saturated nitriles in a highly selective manner. (Figure presented.).
- Yu, Xiao-Ye,Wang, Peng-Zi,Yan, Dong-Mei,Lu, Bin,Chen, Jia-Rong,Xiao, Wen-Jing
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p. 3601 - 3606
(2018/09/18)
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- Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH)
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Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppressi
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- 6-Alkylindan-1-ones as fragrances
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The invention relates to the use of 6-alkylindan-1-ones as fragrances, to a process for their preparation, to fragrance mixtures comprising 6-alkylindan-1-ones, and to perfumed products comprising 6-alkylindan-1-ones.
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- A regiospecific synthesis of 3,3,6-trimethylindan-1-one
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A novel, regiospecific synthesis of 3,3,6-trimethylindan1-one (5) was achieved. The route to 5 was 6 steps and proceeded in 27% overall yield.
- Vogt,Molino,Robichaud
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p. 679 - 684
(2007/10/03)
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- Steric Effects. A Study of a Rationally Designed System
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The principles for the rational design of systems suitable for the study of steric effects are defined.A suitable molecular framework was synthesized and a study of internal rotaition by dynamic NMR spectroscopy (DNMR) 0f 33 derivatives, differing principally in the nature of the molecular fragment (X), showed the following. (i) For 1 (Y = Me; X = halogen) the rotaition barriers (ΔG excit.) increase smoothly and monotonically with the van der Waals radius of X (rx), which permits the estimation of effective rx for fragments of lower symmetry. (ii) The rotational barriers are the sum of additive contributions, designated interference values (IH-X), which can be used to predict the rotational barriers in 2,2'-disubstituted biphenyls. (iii) A simple geometrical parameter, apparent overlap (r*), which is related to the distortion of the framework in the transition state, is proposed and found to have an excellent linear correlation with the barrier to rotation in 2,2'-disubstituted biphenyls. (iv) This correlation can be used for a semiquantitative estimation of rotational barriers in biaryls and other systems.
- Bott, Garry,Field, Leslie D.,Sternhell, Sever
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p. 5618 - 5626
(2007/10/02)
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- Occupational medicine in Belgium
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In 1965 occupational medicine was extended to all Belgian industries. In view of the economical structure of the country, most of them became affiliated to occupational medical services. The supervision of workers' health and of the problems of industrial hygiene are the two main objectives of such a service.
- Brouwers
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p. 189 - 194
(2007/10/05)
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