- Efficient and environmentally friendly synthesis of 2-amino-imidazole
-
A new and efficient method for the preparation of 2-amino-imidazole 3 was developed. Starting from cheap commodities O-methyl-iso-urea sulphate and 2-aminoacetaldehyde-acetales the desired product is isolated through a very simple work-up in a good yield.
- Weinmann, Hilmar,Harre, Michael,Koenig, Klaus,Merten, Erik,Tilstam, Ulf
-
-
Read Online
- Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles
-
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
- -
-
-