Synthesis and opioid activity of new fentanyl analogs
Three new fentanyl analogs (compounds 3-4-5) have been synthesized and evaluated for antinociceptive properties using the writhing test. The analgesic property of the active compound, N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl)] propenamide (
Giron, Rocio,Abalo, Raquel,Goicoechea, Carlos,Martin, Ma Isabel,Callado, Luis F,Cano, Carolina,Goya, Pilar,Jagerovic, Nadine
ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to arylamide derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit,of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such c
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Page/Page column 230; 231
(2017/11/10)
Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.
The synthesis of new fentanyl analogues in which the benzene ring of the propioanilido group has been replaced by phenylpyrazole is described. Antinociceptive activity was evaluated using the writhing and hot plate tests in mice. Two compounds, and, showe
Jagerovic, Nadine,Cano, Carolina,Elguero, Jose,Goya, Pilar,Callado, Luis F,Meana, J Javier,Giron, Rocio,Abalo, Raquel,Ruiz, David,Goicoechea, Carlos,Martin, M A Isabel
p. 817 - 827
(2007/10/03)
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