- Cannabidiol derivative as well as preparation method and medical application thereof
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The invention relates to a cannabidiol derivative and application thereof in medicine, in particular to a pyrimidine derivative as shown in a general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, and definition of each substituent in the general formula (I) is the same as that in the specification.
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Paragraph 0125; 0128; 0135-0140
(2021/07/10)
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- BROMODOMAIN INHIBITORS FOR TREATING DISEASE
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Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.
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Paragraph 0230-0231
(2016/03/19)
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- TRISUBSTITUTED BORON-CONTAINING MOLECULES
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This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.
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Page/Page column 98
(2011/02/24)
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- Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2′,2′- dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents
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In a continued study, 23 3′R,4′R-di-O-(-)-camphanoyl-2′, 2′-dimethyldihydropyrano[2,3-f]chromone (DCP) derivatives (5-27) were synthesized, and screened for anti-HIV activity against both a non-drug-resistant NL4-3 strain and multiple reverse transcriptas
- Zhou, Ting,Shi, Qian,Chen, Chin-Ho,Zhu, Hao,Huang, Li,Ho, Phong,Lee, Kuo-Hsiung
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experimental part
p. 6678 - 6689
(2010/10/18)
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- Statistical molecular design, parallel synthesis, and biological evaluation of a library of thrombin inhibitors
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A library of thrombin inhibitors has been designed using statistical molecular design. An aromatic scaffold was used, with three varied positions corresponding to three pockets at the active site of thrombin (the S-, P-, and D-pockets). The selection was
- Linusson,Gottfries,Olsson,?rnskov,Folestad,Nordén,Wold
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p. 3424 - 3439
(2007/10/03)
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- Amidino derivatives and their use as thrombin inhibitors
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There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
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- Propiophenone derivatives and process for preparing the same
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A propiophenone derivative of the formula (I): wherein OX is a hydroxy group which may optionally be protected, Y is a lower alkyl group, and Z is a beta -D-glucopyranosyl group wherein one or more hydroxy groups may optionally be protected, or a pharmace
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- GUANIDINO PROTEASE INHIBITORS
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Compounds of the formula: STR1 wherein R 1--R 4, R. sup.7--R 8, R a, R b, R c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.
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- BIOLOGICALLY ACTIVE PHENOLIC METABOLITES OF A VERTICICLADIELLA SPECIES
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The metabolites produced when a Verticicladiella species (Canadian Forestry Service strain C728), the causative agent of the black stain root disease of many conifers, is grown in liquid culture have been investigated.Orcinol, orcinol monomethyl ether, 1,3,6,8-tetrahydroxyanthraquinone, and the α-L-rhamnopyranosides of orcinol and orcinol methyl ether have been isolated and indentified.Orcinol methyl ether and its rhamnoside both show antibacterial activity and orcinol methyl ether also inhibits the growth of pine germlings.The general antibacterial activity of 5-alkylresorcinols and their monomethyl ethers is reported.-Key Word Index-Verticicladiella sp.; Deuteromycontina; blue-stain fungus; phytotoxin; phenols; methylorcinol rhamnoside; phenol monomethyl ethers; antiseptics.
- Ayer, William A.,Browne, Lois M.,Lovell, Sarah H.
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p. 2267 - 2272
(2007/10/02)
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