Palladium(II)-Catalyzed C(sp2)-H Bond Activation/C-N Bond Cleavage Annulation of N-Methoxy Amides and Arynes
The Pd(II)-catalyzed C-H bond activation/C-N bond cleavage annulation reaction of N-alkyoxyamide aryne is developed to synthesize 9,10-dihydrophenanthrenone derivatives. This reaction exhibited good functional group compatibility with yields up to 92%. Detailed mechanistic studies showed that the key to C-N bond cleavage is the formed eight-membered palladacycle intermediate undergoing nucleophilic addition to the carbonyl group, which provides a new and practical way for N-alkoxyamide directed C-H bond activation.
Cheng, Xiu-Fen,Yu, Ting,Liu, Yi,Wang, Nan,Chen, Zhenzhen,Zhang, Guang-Lu,Tong, Lili,Tang, Bo
supporting information
p. 2087 - 2092
(2022/04/07)
INVESTIGATIONS IN THE FIELD OF SEMISYNTHETIC PENICILLINS. XIV. 1-(ALKOXYPHENYL)CYCLOPENTYL-1-PENICILLINS
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Mndzhoyan, Sh. L.,Tsinker, M. G.,Ovakimyan, A. R.,Ter-Zakharyan, Yu. Z.,Oganyan, Sh. G.
p. 179 - 184
(2007/10/02)
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