- DEHALOGENO COMPOUNDS
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3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substitunets as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE . Thus these compounds are usable as drugs.
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- Synthesis and biological testing of non-fluorinated analogues of Levofloxacin
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Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the antibacterial quinolone Levofloxacin were synthesized and tested.
- Gray, Jeffrey L.,Almstead, Ji-In K.,Gallagher, Corey P.,Hu, X. Eric,Kim, Nick K.,Taylor, Cynthia J.,Twinem, Tracy L.,Wallace, Cynthia D.,Ledoussal, Benoit
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p. 2373 - 2375
(2007/10/03)
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