- Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate
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An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.
- Barré, Ana?s,T?nta?, Mihaela-Liliana,Alix, Florent,Gembus, Vincent,Papamica?l, Cyril,Levacher, Vincent
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p. 6537 - 6544
(2015/10/05)
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- Sialyltransferase inhibitors: Consideration of molecular shape and charge/hydrophobic interactions
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In order to evaluate the importance of molecular shape of inhibitor molecules and the charge/H-bond and hydrophobic interactions, we synthesized three types of molecules and tested them against a sialyltransferase. The first type of compounds were designe
- Kumar, Rishi,Nasi, Ravindranath,Bhasin, Milan,Khieu, Nam Huan,Hsieh, Margaret,Gilbert, Michel,Jarrell, Harold,Zou, Wei,Jennings, Harold J.
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- Stereoselective synthesis of brevianamide e
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The hydroxypyrroloindolenine (Hpi) motif forms the fundamental core of the pentacyclic natural product, brevianamide E, the concise stereoselective synthesis of which, via oxidative cyclization, is described.
- Zhao, Liang,May, Jonathan P.,Huang, Jack,Perrin, David M.
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supporting information; experimental part
p. 90 - 93
(2012/02/15)
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- Artificial molecular clamp: A novel device for synthetic polymerases
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Synthetic polymerases composed of a cyclodextrin (CD) dimer yield high-molecular-weight polymers of cyclic esters without using solvents and co-catalysts. One CD moiety is attached to the active site of a supramolecular catalyst and propagates the polymerization by serving as artificial molecular clamp (see picture). The other CD moiety initiates the ring-opening polymerization. Copyright
- Takashima, Yoshinori,Osaki, Motofumi,Ishimaru, Yoshihiro,Yamaguchi, Hiroyasu,Harada, Akira
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supporting information; experimental part
p. 7524 - 7528
(2011/10/04)
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- Methyl 2-((succinimidooxy)carbonyl)benzoate (MSB): a new, efficient reagent for N-phthaloylation of amino acid and peptide derivatives.
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A new, efficient, and readily available reagent, methyl 2-((succinimidooxy)carbonyl)benzoate (MSB), for N-phthaloylation of amino acids and amino acid derivatives is described. The phthaloylation procedure is simple and racemization-free and gives excellent results with alpha-amino acids, alpha-amino alcohols, dipeptides, alpha-amino carboxamides, and alpha-amino esters.
- Casimir, J Richard,Guichard, Gilles,Briand, Jean-Paul
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p. 3764 - 3768
(2007/10/03)
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