- Novel drug delivery compositions
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The present invention provides for a novel molecules useful for delivery of compounds to a mammal, more particularly for the intracellular delivery of nucleotides, nucleotide analogues or compounds with a heterocyclic base. Also provided for are novel therapeutic complexes comprising novel molecules complexed with nucleotide analogues or heterogeneous or homogenous oligomers comprised of nucleotide analogues.
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Page/Page column 13
(2010/11/25)
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- Chiral 2-Thioxotetrahydro-1,3-O,N-heterocycles from Carbohydrates. 2. Stereocontrolled Synthesis of Oxazolidine Pseudo-C-nucleosides and Bicyclic Oxazine-2-thiones
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Chiral, sugar-derived oxazolidine-2-thiones having a pseudo-C-nucleoside structure, as well as bicyclic 2-thioxotetrahydro-1,3-oxazines, have been prepared by intramolecular cyclization of 6-deoxy-6-isothiocyanatoaldoses or -aldopyranosides, respectively.The reaction proceeds with total regioselectivity and no need for protection of the secondary hydroxyl groups.A one-pot procedure for the synthesis of the five-membered heterocycles from the corresponding amino sugars is aslo reported.The six-membered analogs have a cis- or trans-decalin-type core depending on the configuration of the sugar precursor.
- Fernandez, Jose M. Garcia,Mellet, Carmen Ortiz,Fuentes, Jose
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p. 5192 - 5199
(2007/10/02)
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