- Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs
-
The terpenoidal oxaliplatin derivatives (6) and (12) were newly synthesized using 2β,3α-dihydroxy-11-oxo-18β-olean-12-ene-30-oic acid (1) and 2α,2β-dihydroxy-18β-ursan-12-ene-28-oic acid (7) as starting materials. The synthesized compounds were evaluated for their cytotoxicity and antioxidant activities and were compared to Oxaliplatin and vitamin C as positive controls. Some of the compounds exhibited better cytotoxicity and antioxidant activities than the reference controls. The detailed synthesis, spectroscopic data, toxicity (LD50) and pharmacological screening for the synthesized compounds were reported.
- Amr, Abd El-Galil E.,Ali, Korany A.,Abdalla, Mohamed M.
-
-
Read Online
- COMPOUNDS FOR REDUCING GLUCOCORTICOIDS, AND METHODS OF TREATMENT THEREOF
-
A method for reducing glucocorticoids in an animal in need thereof comprising the use of compounds of the formula (I), wherein the definitions for R', R1-R11 and n are as disclosed in the description. The compounds of formula (I) are for the treatment or prevention of a glucocorticoid-related disorder for maintaining bone density, maintaining and improving the immune system, treating Cushing' s syndrome, treating obesity, improving reproduction efficiency, treating metabolic disorder, treating hypertension, treating hyperglycemia, treating insulin resistance, treating type 2 diabetes, and/or aiding in cancer and immune therapies
- -
-
-
- Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases
-
The synthesis and biological evaluation of corosolic acid derivatives and related compounds as inhibitors of rabbit muscle glycogen phosphorylase a is described. Within this series of compounds, 8 (IC50 = 7.31 μM), 12d (IC50 = 3.26 μM), and 12e (IC50 = 5.1 μM) exhibited more potent activities than the parent compound 1 (IC50 = 20 μM). SAR of these compounds is also discussed.
- Wen, Xiaoan,Xia, Jun,Cheng, Keguang,Zhang, Liying,Zhang, Pu,Liu, Jun,Zhang, Luyong,Ni, Peizhou,Sun, Hongbin
-
p. 5777 - 5782
(2008/04/03)
-
- NOVEL STRUCTURAL ANALOGS OF COROSOLIC ACID HAVING ANTI-DIABETIC AND ANTI-INFLAMMATORY PROPERTIES
-
This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are as indicated below in each of said analogs: 1. R1 = COCH3, R2/sub
- -
-
Page/Page column 15
(2008/06/13)
-
- Triterpenoids and other compounds from Salvia roborowskii Maxim
-
Two new triterpenoids, 2α-hydroxy-3β-methoxyurs-12-en-28-oic acid and 3α-hydroxy-2α-methoxyurs-12-en-28-oic acid as well as 25 known compounds were isolated from the whole plant of Salvia roborowskii Maxim. Their structures were elucidated by means of spectral data and chemical transformation. This is the first report on the chemical constituents of this plant. The presence of eugenyl β-D-glucopyranoside 22 in a plant of the genus Salvia is also reported for the first time.
- Wang,Li,Li,Li
-
p. 420 - 422
(2007/10/03)
-
- Chemical Constituents from the Root and Aerial Parts of Rosa taiwanensis
-
The root and aerial parts of Rosa taiwanensis Nakai contain the chemical constituents phenols, unsaturated acids, liolide, abscisic acid, flavones, sterols, lupeol, betulin, betulinic acid, oleanolic acid and ursolic acid derivatives.Among them, 2α,3α-dihydroxyurs-12,19-dien-28-oic acid and its C-3 epimer are new compounds.Key Words Rosa taiwanensis; Rosaceae; Aerial part; Root; Flavones; Ursolic acid derivatives; Lupeol; Betulin; Oleanolic acid.
- Yang, Shen-Chyun,Fang, Jim-Min,Cheng, Yu-Shia
-
p. 573 - 578
(2007/10/02)
-
- URSANE TRITERPENOIDS FROM NEPETA ERIOSTACHIYA
-
From the aerial parts of Nepeta eriostachiya two rare ursane triterpenoids, 2α,3α-dihydroxyurs-12-en-28-oic acid and 2α,3β-dihydroxyurs-12-en-28-oic acid, together with a new triterpene, nepetoic acid identified as 2α-methoxy-3β-hydroxyurs-12-en-28-oic acid were isolated as their methyl esters.Their structures were established by chemical and spectroscopic means.
- Bhandari, S. P. S.,Garg, H. S.,Agrawal, P. K.,Bhakuni, D. S.
-
p. 3956 - 3958
(2007/10/02)
-
- THE CYTOTOXIC PRINCIPLES OF HYPTYS CAPITATA AND THE STRUCTURES OF THE NEW TRITERPENES HYPTATIC ACID-A AND -B
-
Bioassay-directed franctionation of a methanolic extract of Hyptis capitata has led to the isolation and characterization of five triterpene acids which include the new hyptatic acids-A and -B in addition to the known 2α-hydroxyursulic acid, tormentic acid and maslinic acid.Spectral data in conjuction with X-ray analysis of the methanol solvate of hyptatic acid-A established the structures of these compounds.Hyptatic acid-A and 2α-hydroxyursolic acid demonstrated significant in vitro cytotoxicity in human colon HCT-8 tumour cells.Key Word Index - Hyptis capitata; Labiatae; cytotoxicity; triterpenes; hyptatic acid-A; hyptatic acid-B; tomentic acid; maslinic acid; 2α-hydroxyursolic acid.
- Yamagishi, Takashi,Zhang, De-Cheng,Chang, Jer-Jang,McPhail, Donald R.,McPhail, Andrew T.,Lee, Kuo-Hsiung
-
p. 3213 - 3216
(2007/10/02)
-
- LAGRENYL ACETATE AND LAGERENOL, TWO TETRACYCLIC TRITERPENOIDS WITH THE CYCLOARTANE SKELETON FROM LAGERSTROEMIA LANCASTERI
-
Lagerenyl acetate and lagerenol, two new tetracyclic triterpenoids with the cycloartane skeleton, together with four other triterpenoids 2α-hydroxy-3β-E-p-coumaryloxy-urs-12-en-28-oic acid (jacoumaric acid, isolated as its monoacetylmethylcarboxylate derivative), 2α-hydroxyursolic acid (isolated as its diacetate), germanicyl acetate and friedelin, and sitosterol were isolated from the leaves and twigs of Lagerstroemia lancasteri.The structures of lagerenyl acetate and lagerenol were established as 3β-acetoxycycloart-24-one and 3β-hydroxycycloart-24-one, respectively, on the basis of spectral and chemical evidence.Key Word Index - Lagerstroemia lancasteri; Lythraceae; triterpenoids; lagerenyl acetate; lagerenol; 2α-hydroxy-3β-E-p-coumaryloxy-urs-12-en-28-oic acid; 2α-hydroxyursolic acid; germanicyl acetate; friedelin; β-sitosterol.
- Talapatra, Bani,Chaudhuri, Prabir K.,Mallik, Asok K.,Talapatra, Sunil K.
-
p. 2559 - 2562
(2007/10/02)
-