- Bifurcated, modular syntheses of chiral annulet triazacyclononanes.
-
Three chiral 2,6-disubstituted tri-N-methyl azamacrocycles have been prepared by modular methods. These macrocycles were accessed from three chiral 1,4,7-triazaheptanes intermediates that were prepared by two independent routes. The first of these routes
- Argouarch, Gilles,Stones, Graham,Gibson, Colin L,Kennedy, Alan R,Sherrington, David C
-
p. 4408 - 4417
(2007/10/03)
-
- The synthesis of chiral annulet 1,4,7-triazacyclononanes
-
Novel and flexible routes for the synthesis of chiral ring annulet 2,6-disubstituted 1,4,7-trimethyl-1,4,7-triazamacrocycles are described. Efficient macrocyclisations were realised provided that chiral analogues of N,N-bis-[2-(toluene-sulfonylamino)ethyl]-toluene-4-sulfonamide were used as the nucleophilic components. Complexes prepared, in situ, from these 2,6-disubstituted 1,4,7-trimethyl-1,4,7-triazamacrocycles and manganese(II) catalysed the asymmetric epoxidation of styrene with hydrogen peroxide.
- Argouarch, Gilles,Gibson, Colin L,Stones, Graham,Sherrington, David C
-
p. 3795 - 3798
(2007/10/03)
-