- VUV irradiation of carbon dioxide (CO2) and ammonia (NH3) complexes in argon matrix
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In this study, we characterized by FTIR spectroscopy the 1:1 and 2:1 molecular complexes between NH3 and CO2 in argon matrix at low temperature. In addition we tentatively identified the 1:2 molecular complex. The structures of the c
- Bossa,Duvernay,Theulé,Borget,Chiavassa
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p. 211 - 217
(2009/03/11)
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- N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity
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The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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- Glucocorticoid receptor modulators
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The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds. STR1
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- α-and β-amino acid hydroxyethlamino sulfonamides useful as retroviral protease inhibitors
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α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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- Glucocorticoid receptor modulators
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The present invention provides non-steroidal compounds of Formula I, and prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.
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- Piperidine amides as modulators of chemo kine receptor activity
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The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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- Phenylureas. Part 1. Mechanism of the basic hydrolysis of phenylureas
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The mechanism of the hydrolytic decomposition of phenylureas in basic media in the pH range 12 to 14 is investigated. In this pH range a levelling of the rate-pH curve is observed as well as a change of the substituent influence on the hydrolysis rate. These experimental findings suggest the formation of an unreactive side product of the phenylurea in a parasitic side equilibrium at sufficiently high pH. The urea dissociates at the aryl-NH group to give its conjugate base. For the hydrolytic decomposition of phenylureas an addition-elimination mechanism is proposed as has been established for the alkaline hydrolysis of carboxylic acid esters and amides.
- Laudien,Mitzner
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p. 2226 - 2229
(2007/10/03)
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- Synthesis of benzo fused heterocyclic sulfonyl chlorides
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A process for preparing a benzo fused heterocyclic sulfonyl halide comprising reacting a benzo fused heterocyclic compound with an SO3 complex in the presence of a water immiscible, non-reactive solvent, at a temperature of from about 0 DEG C. to about 75 DEG C., cooling, if necessary, to a temperature of from about -25 DEG C. to about 65 DEG C. and then adding oxalyl halide.
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- Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
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PCT No. PCT/US96/00607 Sec. 371 Date Feb. 26, 1998 Sec. 102(e) Date Feb. 26, 1998 PCT Filed Jan. 18, 1996 PCT Pub. No. WO96/22287 PCT Pub. Date Jul. 25, 1996Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein the variables are as defined herein.
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- Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
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PCT No. PCT/US94/09139 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 23, 1994 PCT Pub. No. WO95/06030 PCT Pub. Date Mar. 2, 1995The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as human immunodeficiency virus.
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- alpha - and beta -amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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alpha - and beta -amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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- Carbamic acid: Molecular structure and IR spectra
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Infrared absorption spectra of mixed H2O, NH3 and 12CO2/13CO2 ices subjected to 1 MeV proton irradiation were investigated. The results of analyses of the spectra suggest formation of carbamic acid at low temperatures. The stability of this compound in the solid phase is attributed to intermolecular hydrogen bonding of the zwitter-ion (NH3+COO-) structure.
- Khanna,Moore
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p. 961 - 967
(2007/10/03)
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- Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
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Selected sulfonylalkanoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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- Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
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Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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- β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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- 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS
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The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. STR1 Wherein R 10 and R 20 taken together are: STR2
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- Peroxy carboxylic amino derivatives
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Amino-derivative (poly)peroxycarboxylic acids which have the formula: STR1 wherein the symbols have the following meanings: R, R1, and R2, which may be equal to or different from one another, represent hydrogen atoms, alkyl groups or groups selected from R, R1 and R2, which taken together with the nitrogen atom to which they are linked, give rise to an aliphatic heterocyclic group, all of them being optionally substituted; A represents a (cyclo) alkylene group, an arylene group which may also be condensed with cycloaliphatic groups, a cycloalkylene-alkylene or an alkylene-cycloalkylene group, an arylene-alkylene or an alkylene-arylene group, which may be condensed with cyclo-aliphatic groups wherein said alkylene group may also be interrupted by --CONR3 groups, wherein R3 represents a hydrogen atom or an alkyl or aryl group; X- represents HSO4- or CH3 SO3- ; a process for their preparation; and their use as bleaching agents.
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- Sulphonamidocycloalkane compounds, pharmaceutical compositions containing them, and methods of use thereof
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The present invention provides sulphonamides of the general formula: STR1 wherein R1 and R2, which can be the same or different, are hydrogen or halogen atoms or C1 -C6 -alkyl, trifluoro-methyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N-alkylaminocarbonyl or N,N-dialkylaminocarbonyl radicals or, when R1 and R2 are alkyl radicals ortho to one another, R1 and R2, together with the carbon atoms to which they are attached, form a saturated or unsaturated C5 -C7 -alkylene ring, R3 is a hydrogen atom, an alkyl radical containing up to 6 carbon atoms, an acyl radical, a phenylalkyl or phenylalkenyl radical, the phenyl moiety of which can be substituted by halogen, alkyl or trifluoromethyl, C is a --(CH2)m -- radical, in which m is 0, 1, 2 or 3, or a branched C2 -C5 alkylene radical, whereby a methylene radical --CH2 -- of the group C can be replaced by an oxygen or sulphur atom or by a hydroxymethylene radical --CHOH-- or carbonyl group --CO--, B is a 1,2-, 1,3-, 1,4-cyclohexylidene or 1,2- or 1,3-cyclopentylidene radical.
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- Insect control compounds
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The invention is novel hydrocarbon ethers of aminophenol derivatives, and their use in preventing the proliferation of insects by interfering with their normal development and growth pattern.
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