From precursor to catalyst: The involvement of [Ru(η5- Cp*)Cl2]2 in highly branch selective allylic etherification of cinnamyl chlorides
(RuCp*Cl2)2, a general entry into Cp*Ru sandwich and half-sandwich chemistry was first used as a precatalyst in allylic etherification of cinnamyl chlorides with up to 98:2 regioselectivity (19 examples). Both the solvent effect and the exsiccant reaction condition are crucial to the reactivity and selectivity. Preliminary mechanism studies and the demonstration of Fluoxetine synthesis were presented in this work as well.
Siddappa, Ravi Kumara Guralamatta,Chang, Chih-Wei,Chein, Rong-Jie
supporting information
p. 1031 - 1035
(2014/02/14)
Ring-closing metathesis as a new methodology for the synthesis of monomeric flavonoids and neoflavonoids
Basic flavonoid (flavene) and neoflavonoid (neoflavene) skeletons were successfully synthesized using ring-closing metathesis, showing that this methodology can be used as a central synthetic tool for the synthesis of at least two of the three basic flavonoid classes.