A novel series of imidazole containing histamine H3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have
Jablonowski, Jill A.,Ly, Kiev S.,Bogenstaetter, Michael,Dvorak, Curt A.,Boggs, Jamin D.,Dvorak, Lisa K.,Lord, Brian,Miller, Kirsten L.,Mazur, Curt,Wilson, Sandy J.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
scheme or table
p. 903 - 907
(2009/08/15)
Scalable synthesis of imidazole derivatives
Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.
-
Page/Page column 33; 34
(2008/06/13)
A scalable synthesis of a histamine H3 receptor antagonist
Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.
Mani, Neelakandha S.,Jablonowski, Jill A.,Jones, Todd K.
p. 8115 - 8117
(2007/10/03)
Heterocyclic compounds
Pharmaceutically useful heterocyclic compounds, compositions containing them, and methods of using them, for example, as histamine H3 receptor mediators.
-
(2008/06/13)
More Articles about upstream products of 465615-69-4