- Piperidine and azetidine formation by direct cyclization of diols with N-nonsubstituted sulfonamide under the Mitsunobu conditions utilizing (cyanomethylene)tributylphosphorane (CMBP) and its application to the synthesis of lupinine
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(Cyanomethylene)tributylphosphorane (CMBP) can promote the Mitsunobu reaction of 1,3- and 1,5-diols with N-nonsubstituted sulfonamides, such as tosylamide (TsNH2) and 3,3-dimethoxypropylsulfonamide (DimpsNH2), to prepare azetidine and piperidine ring systems directly. Utilizing this methodology, lupinine, a biologically active piperidine alkaloid, was synthesized.
- Hamaguchi, Takumi,Hishida, Hideyuki,Horikawa, Mitsuyo,Inai, Makoto,Kaku, Hiroto,Kitamura, Kei,Kubo, Akiko,Sonoda, Yuhei,Taniguchi, Yuri,Tsunoda, Tetsuto
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p. 1525 - 1535
(2020/01/28)
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- Catalytic synthesis of oxygenate from alcohol
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The present invention discloses a method for catalytic synthesis of oxygenate from alcohol. At first, a feeding material comprising at least one alcohol is provided. Next, a copper-containing catalyst is provided and the catalyst further comprises at least one metal element selected from the group consisting of the following: zinc, magnesium, and aluminum elements. Following that, a catalytic reaction of the feeding material over the copper-containing catalyst is carried out to synthesize at least one oxygenate.
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Page/Page column 4-8
(2008/06/13)
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