- CYCLIC PEPTIDE ANTIBIOTICS
-
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
- -
-
-
- Pseudoenantiomeric glycoclusters: Synthesis and testing of heterobivalency in carbohydrate-protein interactions
-
Multivalent carbohydrate-protein interactions are key events in cell recognition processes and have been extensively studied by means of synthetic glycomimetics. To date, frequently the valency, i.e. the multiplicity of the ligand attached to a polyvalent
- Brekalo, Jasna,Despras, Guillaume,Lindhorst, Thisbe K.
-
p. 5929 - 5942
(2019/06/24)
-
- Orthogonally protected glycerols and 2-aminodiols: Useful building blocks in heterocyclic chemistry
-
The efficient synthesis of orthogonally protected glycerols, 2-aminopropane-1,3-diols and 2-aminobutane-1,4-diols that can constitute useful tools in heterocyclic chemistry, is reported. These interesting tri-functionalized small synthons were easily prepared from serine or aspartic acid. In addition, these substrates can be readily transformed into their iodide derivatives in very good yields. ARKAT USA, Inc.
- Ollivier, Anthony,Goubert, Marlene,Tursun, Ahmatjan,Canet, Isabelle,Sinibaldia, Marie-Eve
-
experimental part
p. 108 - 126
(2010/10/03)
-
- Parallel synthesis of individual shikimic acid-like molecules using a mixture-operation strategy and ring-closing enyne metathesis
-
Three new diastereomeric shikimic acid analogues (4-amino-3,5-dihydroxyl-cyclohex-1-en-carboxylic acids, 16) bearing a C-4 amino group were synthesized in parallel by a mixture-operation protocol. Ring-closing enyne metathesis (RCEYM) under ethylene atmos
- Hu, Fang,Zhang, Yan-Hong,Yao, Zhu-Jun
-
p. 3511 - 3515
(2008/02/06)
-
- Chemoselective deprotection of cyclic N,O-aminals using catalytic bismuth(III) bromide in acetonitrile
-
Cyclic N,O-aminals can be chemoselectively and efficiently deprotected using a catalytic amount of bismuth(III) bromide in acetonitrile at room temperature. This selectivity was also achieved in the presence of terminal O,O-acetal functionality. The susce
- Cong, Xin,Hu, Fang,Liu, Ke-Gang,Liao, Qing-Jiang,Yao, Zhu-Jun
-
p. 4514 - 4516
(2007/10/03)
-
- Facile Route to 3,5-Disubstituted Morpholines: Enantioselective Synthesis of O-Protected trans-3,5-Bis(hydroxymethyl)morpholines
-
(Equation presented) trans-3,5-Bis(benzyl/terf-butyldiphenylsilyloxymethyl) morpholines, promising candidates for the C2-symmetric class of chiral reagents, were prepared with excellent optical purity. A key step in the synthesis is the couplin
- Dave, Rajesh,Andre Sasaki
-
-