- Preparation of carbon-14 labeled organophosphate pesticides: Chlorfenvinphos
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Synthesis of [vinyl-14C]chlorfenvinphos, utilizing [14C]iodomethane as the source of the label, was accomplished in 28% radiochemical yield by the methylation of 2,4-dichlorobenzoyl chloride, chlorination of the resulting [14C]-2,4-dichloroacetophenone, and condensation of the product with triethylphosphite. The product, isolated as a mixture of E and Z isomere (3.6 and 96.3%, respectively), was obtained in >99% purity and had specific activity 20 mCl/mmol.
- Fudala, Louise,Lewin, Anita H.
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p. 261 - 266
(2007/10/03)
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- REACTIONS OF 2,4- AND 2,6-DICHLOROPHENACYLIDENE HALIDES WITH TRIALKYLPHOSPHITES IN PROTIC SOLVENTS. DIRECT EVIDENCE FOR THE "ENOLATE ANION" PATHWAY
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The reactions of 2,6-dichlorophenacyl and 2,6-dichlorophenacylidene chlorides and bromides with trimethyl and triethyl phosphites have been investigated.The reactivity of 2,6-dichlorophenacylidene chloride and bromide towards trialkyl phosphites was compared with that of 2,4-dichlorophenacylidene chloride and bromide.The influence of methanol, acting as a model protic solvent, on the above mentioned processes has also benn investigated.The mechanism of Perkow reaction of sterically hindered α-haloketones with bulky substituents around the carbonyl center is discussed.
- Mlotkowska, Barbara,Majewski, Piotr,Koziara, Anna,Zwierzak, Andrzej,Sledzinski, Bohdan
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p. 631 - 642
(2007/10/02)
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