cas 4724-10-1, Methyl 3,5-dihydroxyphenylacetate

Articles about 4724-10-1Total 10 be found

First total synthesis of medicinally important 3,4,7-trimethoxy-9,10-dihydrophenanthrene-1,5-diol
The first total synthesis was successfully achieved for biologically active 9,10-dihydrophenanthrene-1,5-diol. The key features of our synthetic approach are Perkin condensation, followed by bromination, palladium mediated intramolecular C-C bond coupling, and selective isopropyl ether cleavage. Synthesized compounds were purified and characterized by IR, 1HNMR, 13CNMR and HRMS/LC-MS.
Gangireddy Venkata, Sivarami Reddy,Narkhede, Umesh C.,Jadhav, Vinod D.,Gangu Naidu, Ch.
p. 1670 - 1673
(2018/03/29)

Synthesis method of natural product of E-2,3',4,5'-tetrahydroxy diphenyl ethylene
The invention discloses a synthesis method of a natural product of E-2,3',4,5'-tetrahydroxy diphenyl ethylene. According to the method, 1,3-acetone dicarboxylic acid dimethyl ester is used as a starting raw material; condensation and aromatization reactions are performed to obtain 3,5-dihydroxy-2,4-dicarboxylate methyl phenyl acetate; then, hydrolysis and decarboxylation are performed to obtain 3,5-dyhydroxy phenylacetic acid; the 3,5-dyhydroxy phenylacetic acid and 2,4-dihydroxy benzaldehyde take condensation reaction under the existence of alkali to obtain 3-(3,5-dihydroxy phenyl)-7-hydroxy coumarin; next, open loop decarboxylation reaction is performed under the alkaline condition; the natural product of E-2,3',4,5'-tetrahydroxy diphenyl ethylene is obtained. The method has the advantages that the raw materials are easily obtained; the reaction route is simple and fast; the operation is convenient; the yield is higher.
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Paragraph 0035; 0036; 0044; 0045; 0053; 0054; 0062; 0063

(2017/08/29)

Syntheses of cytosporones A, C, J, K, and N, metabolites from medicinal fungi
The syntheses of the fungal metabolites cytosporones A, (±)-C, and N are reported. And the syntheses of cytosporones J and K are described for the first time. The preparation of racemic cytosporone J and racemic cytosporone K, natural products containing
Beekman, Andrew M.,Barrow, Russell A.
p. 1583 - 1592
(2015/10/20)

A diastereoselective formal synthesis of berkelic acid
A formal synthesis of berkelic acid is reported. The strategy employs the combination of a chiral exocyclic enol ether and an achiral isochromanone to afford the chroman spiroketal core via a base-triggered generation and cycloaddition of an o-quinone met
Wenderski, Todd A.,Marsini, Maurice A.,Pettus, Thomas R. R.
supporting information; experimental part
p. 118 - 121
(2011/04/15)

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
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Page/Page column 28

(2008/06/13)

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
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Page/Page column 24

(2010/11/27)

Preparation and catalytic properties of resin bound binuclear rhodium tetracarboxylate complexes
4-(4'-Polystyryimethyloxy)-3-carboxylatomethyloxy-1-phenylacetate bis- μ-coordinated rhodium(II) diacetate complex, a resin-bound analogue of dirhodium tetraacetate in which two adjacent μ-bridging acetate moleties are covalently linked, serves as an efficient, stable and re-useable immobilised alkene hydrofomylation and hydrogenation catalyst.
Andersen, Jo-Ann M.,Karodia, Nazira,Miller, David J.,Stones, Duane,Gani, David
p. 7815 - 7818
(2007/10/03)

Synthesis of 3,5-dihydroxyphenylglycine derivatives and the C-terminal dipeptide of vancomycin
Syntheses of optically active 3,5-DMPG and racemic 3,5-DHPG, the latter suitably protected for incorporation into linear peptides modelled on vancomycin, are described and a synthesis of the optically pure protected C-terminal dipeptide of vancomycin is p
Stone, Martin J.,Maplestone, Rachael A.,Man, Shirley K. Rah,Williams, Dudney H.
p. 2663 - 2666
(2007/10/02)

Drugs derived from Cannabinoids. Part 8. The Synthesis of Side-chain Analogues of Δ6a,10a-Tetrahydrocannabinol
The continuation of studies on the synthesis of side-chain analogues of Δ6a,10a-tetrahydrocannabinol as potential therapeutic agents has led to the syntheses of a possible metabolite 1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzopyran-3-ylacetic acid (1) and 2-(1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzopyran-3-yl)pent-4-ynoic acid (17c).The Pechmann condensation of ethyl 4-methyl-2-oxocyclohexane-1-carboxylate with methyl 3,5-dihydroxyphenylacetate (11), followed by Grignard reaction, was utilized to produce the pyran (1).The key step in the synthesis of the propargylacetic acid (17c) was propargylation of the malonate (15) under phase-transfer catalysis.
Meltzer, Peter C.,Dalzell, Haldean C.,Razdan, Raj K.
p. 2825 - 2829
(2007/10/02)