- SULFONAMIDE AND SULFINAMIDE PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES
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The present invention provides compounds and pharmaceutical compositions for treating neurological diseases such as multiple sclerosis.
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Paragraph 0155; 0156
(2015/09/23)
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- THIENOPYRIMIDINES, PROCESS FOR PREPARING THE SAME AND USE THEREOF
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The present invention provides a thienopyrimidine compound, represented by the formula???[wherein, R1 is C1-4 alkyl, R2 is (1) phenyl optionally having a substituent such as amino, mono C1-4 alkylamino and di C1-4 alkylamino, or (2) a heterocyclic group optionally having a substituent such as amino, mono C1-4 alkylamino and di C1-4 alkylamino and the like, R3 is a hydrogen atom or C1-4 alkyl, R4 is C1-4 alkyl optionally having a substituent such as C1-4 alkoxy-carbonyl, carboxyl, mono C1-4 alkylamino and N-C1-4 alkyl-N-C7-10 aralkylamino and the like] or a salt thereof, which has antagonistic action for gonadotropin-releasing hormone.
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- SYNTHESE DE COORDINATS MACROCYCLIQUES POLYAZOTES COMPORTANT UNE FONCTION AMINE SECONDAIRE DISCRIMINEE
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A synthetic scheme is elaborated to prepare two polyaza-macrocycles in which one nitrogen atom is distinct from the others.Thus, (tri-N-methyl)-1,4,7,10-tetraazacyclododecane and (tetra-N-methyl)-1,4,7,10,13-pentaazacyclopentadecane were synthesised.Throu
- Pilichowski, J. F.,Lehn, J. M.,Sauvage, J. P.,Gramain, J. C.
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p. 1959 - 1964
(2007/10/02)
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- Studies of Pendant-arm Macrocyclic Ligands. Part 1. Synthesis of Two New Penta-aza Ligands, and Observation of pH-Dependent Reversible Equilibria between Trigonal-bipyramidal and Square-planar Forms of their Nickel(II) and Copper(II) Complexes. Crystal Structure of a Trigonal-bipyrami...
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Two new pendant-arm quinquedentate aza-macrocyclic ligands have been prepared, and their nickel(II) and copper(II) complexes found to undergo reversible rearrangements between approximately trigonal-bipyramidal structures at neutral pH, and protonated square-planar structures at low pH in which the pendant arms are protonated and non-co-ordinating.The crystal structure of 1>2 1 = 11-(2-dimethylaminoethyl)-1,4,7,11-tetra-azacyclotetradecane> establishes an approximately trigonal-bipyramidal geometry for the complex.Crystals are orthorhombic, space group Pna21, with a = 14.559(3), b = 15.337(3), c = 10.322(3) Angstroem, and Z = 4.The final R was 0.108 for 978 observed reflections with I/?(I) > 2.5.The axial N-Ni-N bond angle is 172(1) deg, and and the equatorial bond angles are 107(2), 107(1), and 144(2) deg.Ni-N distances range from 2.04(2) to 2.17(3) Angstroem.The nickel(II) and copper(II) complexes of L1 are isomorphous.
- Alcock, Nathaniel W.,Kingston, Robert G.,Moore, Peter,Pierpoint, Colin
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p. 1937 - 1944
(2007/10/02)
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