Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.
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Page/Page column 676-677
(2020/10/21)
HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.
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Paragraph 00226
(2017/07/27)
ANTIBACTERIAL COMPOUNDS
Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man
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Page 76; 77
(2008/06/13)
Synthesis of novel substituted isoquinolones
A series of novel substituted isoquinolones have been synthesised. This has been achieved by two routes, either Curtius rearrangment of cinnamic acids or via an isoquinoline N-oxide.
Briet, Nicolas,Brookes, Michael H,Davenport, Richard J,Galvin, Frances C.A,Gilbert, Philip J,Mack, Stephen R,Sabin, Verity
p. 5761 - 5766
(2007/10/03)
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