- Synthesis of 7-Azidofurazano[3,4-b]tetrazolopyrazine and isomer's structure in different polarity solvents
-
7-Azidofurazano[3,4-b]tetrazolopyrazine (FSZPA) was synthesized via methoxylation, nitration hydrazinolysis and azidation, using 2,6- dichloropyrazine as a starting material. The structures of 7-azidofurazano[3,4- b]tetrazolopyrazine and intermediates were identified by FTIR, NMR and elemental analysis. 15N and 13C NMR spectra showed three isomer forms resulting from the reversible opening and closing between asido and tetrazole depending on polarity of the solvents.
- Guo, Tao,Liu, Min,Jiang, Jun,Qiu, Shao-Jun,Ge, Zhong-Xue
-
-
Read Online
- An unexpected synthesis of 7-azidofurazano[3,4-b]tetrazolopyrazine
-
In the course of our program focused on the preparation of high-nitrogen content heterocyclic compounds, we wish to report an original synthesis of the tricyclic 7-azidofurazano[3,4-b]tetrazolopyrazine via an unprecedented reaction between 2,6-dimethoxy-3,5-dinitropyrazine and hydrazine hydrate. This compound was identified by an X-ray diffraction analysis. Further studies of its structure by 15N and 13C NMR spectroscopy were carried out in different solvents. This allowed us to observe a noteworthy equilibrium involving three forms resulting from the reversible opening of a tetrazole ring.
- Guillou,Jacob,Terrier,Goumont
-
-
Read Online
- A method for synthesizing dibromo compounds
-
The present invention belongs to the field of synthesis technology of compounds, specifically disclosed a method of synthesis of dibromo compounds. The method of the present invention takes a dichloro compound as a raw material, first reacts with sodium methanol to form a dimethoxy compound, and then reacts with a bromination reagent to give a dibromo compound. The method of the present invention is not only mild reaction conditions, simple operation, and the reaction product is single, through simple post-treatment, and then the target product can be obtained at a high yield, it is expected to be developed as an industrial production method.
- -
-
Paragraph 0031-0037
(2022/02/24)
-
- Green Oxidation Process in the Synthesis of LLM-105 with H2O2/Peroxotungstate System and its Theoretical Study
-
A new catalytic system was developed and applied to the oxidation reactions involved in the synthesis of LLM-105, in which protonated peroxotungstate combining chitosan was used as catalyst. With H2O2as oxidant, good to excellent yields could be achieved in the synthesis of pyrazine-1-oxide, 2,6-dimethoxypyrazine-1-oxide, 2,6-dichloropyrazine-1-oxide, and 2-chloro-6-methoxypyrazine-1-oxide without any addition of trifluoracetic acid, which provided a significant exploration toward novel and environmentally benign synthetic route for LLM-105. Theoretical studies were also carried out with Gaussian 03 to evaluate the oxidation process. All of the calculated data matched well with our experimental results.
- Zhu, Jie,Zhao, Xue-Jing,Wang, Peng-Cheng,Lu, Ming
-
p. 1386 - 1394
(2016/09/23)
-
- Synthetic method for 2,6-diamino-3,5-dinitro-1-oxypyrazine
-
The invention relates to a synthetic method for a compound, especially to a synthetic method for 2,6-diamino-3,5-dinitro-1-oxypyrazine. The method comprises the following steps: subjecting sodium methoxide and dibromopyrazine to methylation; then carrying
- -
-
Paragraph 0004; 0007
(2016/10/08)
-
- CHEMICAL COMPOUNDS AND PROCESSES
-
The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
- -
-
Page/Page column 76-77
(2008/12/06)
-
- Studies on pyrazines, Part 39.1 Synthesis and acidic hydrolysis of 2-hydroxy-5-methoxypyrazine
-
2-Hydroxy-5-methoxypyrazine was synthesised in a three-step reaction sequence starting from aminopyrazine. The product was extensively destroyed on acidic workup without forming 2,5-dihydroxypyrazine.
- Sato, Nobuhiro,Mizuno, Akio
-
p. 747 - 749
(2007/10/03)
-
