- SYNTHESIS OF MORIN AND MORIN DERIVATIVES
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The invention relates to a method for directly producing morin derivatives and high-purity morin of formula (I). The invention also relates to morin derivatives and high-purity morin that can be obtained using the claimed method.
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Paragraph 0039
(2020/11/24)
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- The total synthesis of (±)-sanggenol F
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A concise and efficient total synthesis of sanggenol F (1) in racemic form has been completed via a sequence of 15 steps with an overall yield of 3.1%, starting from commercially available 2,4,6-trihydroxyacetophenone. Meanwhile, a semisynthesis of sanggenol F racemate has also been achieved in 11.1% overall yield via 7 steps with naturally-occurring morin (2) as the starting material. One step and a stepwise approach were employed to construct the two prenyl side chains at 2- and 6-positions by Claisen rearrangement reaction.
- Sheng, Xiao,Jia, Xin-Yu,Tang, Fei,Wang, Yang,Hou, Ai-Jun
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p. 3485 - 3491
(2017/06/01)
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- Pharmacophore and docking-based hierarchical virtual screening for the designing of aldose reductase inhibitors: Synthesis and biological evaluation
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A set of 54 studied flavonoid inhibitors of aldose reductase (ALR2) enzyme has been utilized for pharmacophore modeling and 3D-QSAR analysis using "PHASE" program of Schr?dinger software. The generated pharmacophore model (AADRR.1109) was challenged to screen "PHASE" database to identify new ALR2 inhibitors. The retrieved hits were employed for docking analysis and pharmacokinetic parameter calculation to obtain orally active molecules. To predict the activity of final retrieved hits, 3D-QSAR model was developed, and the best model was selected on the basis of various statistical parameters (Rtrain 2 0.719; Q test 2 0.647 and SD 0.663). Totally five screened molecules which showed better enhanced predicted activity were synthesized and evaluated for in vitro ALR2 inhibitory activity. All tested molecules showed ALR2 inhibitory activity (IC50) below 40 μM. Additionally, the free radical scavenging potential of synthesized molecules was also determined which played a useful role to control the progression of diabetic complications. All molecules showed good antioxidant potential, thus the designed molecules, in future, could be explored to ameliorate the development of diabetic complications.
- Vyas, Bhawna,Singh, Manjinder,Kaur, Maninder,Silakari, Om,Bahia, Malkeet Singh,Singh, Baldev
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p. 609 - 626
(2016/03/08)
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- Flavonol glycosides from muehlenbeckia platyclada and their anti-inflammatory activity
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A new flavonol, morin-3-O-α-rhamnopyranoside (1), along with four known flavonols, kaempferol 3-O-α-rhamnopyranoside (2), kaempferol 3-O-β-glucopyranoside (3), quercetin 3-O-α-rhamnopyranoside (4) and (+)-catechin (5), were isolated from the methanolic ex
- Yen, Chiao-Ting,Hsieh, Pei-Wen,Hwang, Tsong-Long,Lan, Yu-Hsuan,Chang, Fang-Rong,Yang-Chang
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experimental part
p. 280 - 282
(2009/10/15)
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- Method for suppressing sorbate- and/or sorbic acid-induced discoloration
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Compositions which comprise sorbic acid and/or one or more sorbates, and a flavonoid and/or flavonoid derivative, a method for the preparation thereof, and their use.
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