TBAF-assisted copper-catalyzed N-arylation and benzylation of benzazoles with aryl and benzyl halides under the ligand/base/ solvent-free conditions
(Equation Presented) TBAF-assisted N-arylation and benzylation of benzazoles such as 1H-benzimidazole, 1H-indole, and 1H-benzotriazole with aryl and benzyl halides have been demonstrated under the ligand/base/solvent-free conditions. In the presence of CuBr2 and TBAF (n-Bu4NF), the azoles underwent N-arylation and benzylation with aryl and benzyl halides smoothly in moderate to good yields. It is noteworthy that the reaction is conducted under the ligand/base/solvent-free conditions.
Reduction of the isolated double bond in bis(N- alkenylhenzimidazole)Pd(II) complexes with KBH4
Palladium(II)-promoted vicinal diamination of N-alkenylbenzimidazoles has been investigated. Dichlorobis(1(alkenyl)benzimidazole)palladium(II) complexes were identified as initial reaction products which proved to be rather inert to the subsequent oxidati