- TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS
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The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.
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Paragraph 0121-0122
(2021/07/17)
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- New furanoflavanoids, intestinal α-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.)
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A bioassay-guided fractionation and chemical examination of antihyperglycemic root extract of Derris indica resulted in isolation and characterization of two new furanoflavanoids (1, 2) along with thirteen known compounds (3-15). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested in vitro for intestinal α-glucosidase inhibitory and DPPH radical activity. New compounds (1, 2) displayed moderate intestinal α-glucosidase inhibitory as well as free radical scavenging activity. Other compounds also displayed varying degrees of moderate intestinal α-glucosidase inhibitory activity. Pongamol (6) displayed potent intestinal α-glucosidase inhibition.
- Ranga Rao,Tiwari, Ashok K.,Prabhakar Reddy,Suresh Babu,Ali, Amtul Z.,Madhusudana,Madhusudana Rao
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scheme or table
p. 5170 - 5175
(2009/12/01)
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- Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors
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Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in m
- Dixit, Manish,Tripathi, Brajendra K.,Tamrakar, Akhilesh K.,Srivastava, Arvind K.,Kumar, Brijesh,Goel, Atul
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p. 727 - 734
(2007/10/03)
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- A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers
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Benzofurans functionalized with hydroxy and acetyl functionalities are not only the core structures found in a large number of biologically important natural products, but also the vital precursors for several naturally occurring furanoflavonoids. Numerou
- Dixit, Manish,Sharon, Ashoke,Maulik, Prakas R.,Goel, Atul
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p. 1497 - 1502
(2007/10/03)
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- Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.
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Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4″,5″,6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa. Chrysophanol, calodenone, lophirone A and lophirone H were isolated from this plant for the first time. The structures of all the isolated compounds were confirmed by 1D and 2D spectroscopic data. These compounds were tested for analgesic and anti-inflammatory activity. All the new compounds showed good analgesic and anti-inflammatory activity. A simple and facile method for the cleavage of benzyl ethers using I2 in trigol is also reported.
- Anuradha,Srinivas, Pullela V.,Ranga Rao,Manjulatha,Purohit, Muralidhar G.,Madhusudana Rao
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p. 6820 - 6826
(2007/10/03)
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- Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors
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Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in mu
- Dixit, Manish,Tripathi, Brajendra K.,Srivastava, Arvind K.,Goel, Atul
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p. 3394 - 3397
(2007/10/03)
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- Amberlyst 15-catalyzed efficient synthesis of 5-acetyl-4-hydroxy-coumarone and 5-acetyl-6-hydroxy-coumarone: Crucial precursors for several naturally occurring furanoflavones
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A novel approach to the total synthesis of naturally occurring furanoflavones and furanochalcones is described. Angular and linear furanoflavones and furanochalcones have been prepared in just four steps, using economical reagents and simple reaction cond
- Goel, Atul,Dixit, Manish
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p. 1990 - 1994
(2007/10/03)
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- Synthesis of furanochromones: A new step in improvement of fluorescence properties
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New 3-hydroxychromone derivatives with a fused furan heterocycle (2-aryl-3-hydroxyfurano[3,2-g]chromones) have been synthesized. This was achieved by an important improvement in the synthetic procedure. Like their parent analogs, these new compounds exhibit two intensive fluorescence emission bands belonging to normal (N*) and tautomer (T*) excited-state forms. While the spectral position of the N* band remains unchanged, the T* band is shifted to longer wavelengths, providing larger separation between the two bands. The new compounds exhibit increased molecular extinction and, more importantly, have about twice as high fluorescence quantum yields. These properties make them very promising for designing new two-band fluorescence sensors.
- Klymchenko, Andrey S.,Ozturk, Turan,Demchenko, Alexander P.
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p. 7079 - 7082
(2007/10/03)
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