- Synthesis of Functionalized Pyrazin-2(1 H)-ones via Tele-Nucleophilic Substitution of Hydrogen Involving Grignard Reactants and Electrophiles
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The reaction of 6-chloro-1-methylpyrazin-2(1H)-one with Grignard reactants followed by quenching with different electrophiles gave access to a variety of 3,6-difunctionalized 1-methylpyrazin-2(1H)-ones. This regioselective three-component reaction represe
- Mampuys, Pieter,Moseev, Timofey D.,Varaksin, Mikhail V.,De Houwer, Johan,Vande Velde, Christophe M. L.,Chupakhin, Oleg N.,Charushin, Valery N.,Maes, Bert U. W.
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- INHIBITOR OF BTK AND MUTANTS THEREOF
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The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.
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(2020/09/12)
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