- Synthetic method 4 - alkoxyphenol compounds
-
The invention discloses a synthetic method of 4 - alkoxyphenol compounds, and belongs to the field of organic chemical synthesis. The method is as follows: An aryl alkyl ether compound is added to the sealing tube. The catalyst dimerization acetic acid rhodium and the oxidizing agent iodobenzene diethyl ester are added, a solvent trifluoroacetic anhydride is added, and the 4 -alkoxyphenol compound is prepared by heating reaction. To the invention, high regioselectivity direct hydroxylation of the aryl alkyl ether compound is realized, the application range of the substrate is wide, the yield is high, the activity after amplification reaction does not significantly decay, and higher yield is still obtained. The utility model has good practicability and industrial application prospect.
- -
-
Paragraph 0076-0078
(2021/09/29)
-
- Para -Selective hydroxylation of alkyl aryl ethers
-
para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.
- Zhu, Runqing,Sun, Qianqian,Li, Jing,Li, Luohao,Gao, Qinghe,Wang, Yakun,Fang, Lizhen
-
supporting information
p. 13190 - 13193
(2021/12/16)
-
- Direct synthesis of anilines and nitrosobenzenes from phenols
-
A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution (iSOAr) process. The products are obtained in good yields under mild and metal-free conditions. The leaving group effect on reactions that proceed through mixed quionone monoketals has also been investigated and a predictive model has been established.
- St Amant,Frazier,Newmeyer,Fruehauf,Read De Alaniz
-
supporting information
p. 5520 - 5524
(2016/07/06)
-
- Photocatalytic synthesis of dihydrobenzofurans by oxidative [3+2] cycloaddition of phenols
-
We report a protocol for oxidative [3+2] cycloadditions of phenols and alkenes applicable to the modular synthesis of a large family of dihydrobenzofuran natural products. Visible-light-activated transition metal photocatalysis enables the use of ammonium persulfate as an easily handled benign terminal oxidant. The broad range of organic substrates that are readily oxidized by photoredox catalysis suggests that this strategy may be applicable to a variety of useful oxidative transformations.
- Blum, Travis R.,Zhu, Ye,Nordeen, Sarah A.,Yoon, Tehshik P.
-
p. 11056 - 11059
(2015/03/30)
-
- Gold-catalyzed dearomative spirocyclization of aryl alkynoate esters
-
Aryl alkynoate esters undergo gold-catalyzed spirocyclization under mild conditions, affording spirolactones in high yields. This approach obviates the need for stoichiometric halogenating reagents typically employed for alkyne activation in related trans
- Aparece, Mark D.,Vadola, Paul A.
-
supporting information
p. 6008 - 6011
(2015/01/08)
-
- Selective one-pot synthesis of various phenols from diarylethanes
-
Various substituted phenols were selectively synthesized by a one-pot reaction through the NHPI-catalyzed aerobic oxidation of 1,1-diarylethanes followed by treatment with dilute sulfuric acid. The Royal Society of Chemistry.
- Nakamura, Ryota,Obora, Yasushi,Ishii, Yasutaka
-
supporting information; experimental part
p. 3417 - 3419
(2009/02/05)
-