Efficient synthesis of γ-keto sulfones by NHC-catalyzed intermolecular Stetter reaction
The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon-carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.
Bhunia, Anup,Yetra, Santhivardhana Reddy,Bhojgude, Sachin Suresh,Biju, Akkattu T.
supporting information; experimental part
p. 2830 - 2833
(2012/07/17)
Sulfones via Mannich bases
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Messinger
p. 603 - 610
(2007/10/05)
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