- Assessment of structural requirements for the monoamine oxidase-B- catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine
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The monoamine oxidase B (MAO-B) substrate properties and distance measurements along the N1-C4 axis of 38 1,4-disubstituted-1,2,3,6- tetrahydropyridine derivatives, including seven newly synthesized MPTP analogs, were used to define
- Mabic, Stéphane,Castagnoli Jr., Neal
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p. 3694 - 3700
(2007/10/03)
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- Synthesis and Dihydropteridine Reductase Inhibitory Effects of Potential Metabolites of the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a nigrostriatal neurotoxin which can cause irreversible parkinsonism in humans and primates by selective destruction of neurons in the substantia nigra.It is possible that MPTP could be metabolized by
- Gessner, Wieslaw,Brossi, Arnold,Shen, Rong-sen,Abell, Creed W.
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p. 311 - 317
(2007/10/02)
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