Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors
A series of substituted 2-aminobenzothiazole compounds have been synthesized and evaluated as nitric oxide synthase (NOS) inhibitors. Compound 14 shows activity in the nM range and is selective for the human neuronal NOS isoform. We have also evaluated the compounds against the rat NOS isoforms. For some of the compounds, there are significant differences in NOS inhibitory activities between the human and rat enzymes. For example, compound 10b has nM activity against the rat nNOS while low μM activity against the human nNOS.
Patman, Joanne,Bhardwaj, Namrta,Ramnauth, Jailall,Annedi, Subhash C.,Renton, Paul,Maddaford, Shawn P.,Rakhit, Suman,Andrews, John S.
p. 2540 - 2544
(2008/02/01)
AMINO BENZOTHIAZOLE COMPOUNDS WITH NOS INHIBITORY ACTIVITY
The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating s
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Page 35
(2008/06/13)
Adsorbent for urokinase containing agarose
Highly pure urokinase can be produced by affinity chromatography on a novel adsorbent which comprises a water insoluble carrier and a ligand united to the carrier. The ligand is shown by the general formula STR1 wherein X is oxygen, sulfur or imino group, and R is amino or carboxyl group.
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(2008/06/13)
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