NOUVELLE SYNTHESE SIMPLE DE NUCLEOSIDE PHOSPHOROTHIOLATE
The O,S-dimethylphosphorochloridate 10 reacts with 5'-O-monomethoxytritylthymidine 11 in pyridine giving nucleoside-3'-thiolophosphodiester 13 in high yields ; in acetonitrile and in the presence of 1-methylimidazole, this reaction leads to the nucleoside-3'-phosphotriester 14 without formation of diester 13.From the latter, the Tp and TpT have been prepared.
Asseline, U.,Thuong, N. T.
p. 847 - 850
(2007/10/02)
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