Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents
Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Although oxime nucleophiles can reactivate the AChE-phosphyl adduct, the adduct undergoes a reaction called aging. No compounds have been described that reactivate the aged-AChE adduct. A family of 2-methoxypyridinium species which reverse aging in a model system is presented. A kinetic study of this system, which includes an SAR analysis, demonstrates that the reaction is highly tunable based on the ring substituents.
Topczewski, Joseph J.,Quinn, Daniel M.
supporting information
p. 1084 - 1087
(2013/04/10)
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