- Reductive acylamination of pyridine N-oxide with aminopyridines and their N-p-tolylsulfonyl derivatives
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Pyridine N-oxide reacts with 2- and 3-aminopyridines and their N-p-tolylsulfonyl derivatives in alkaline medium in the presence of p-toluenesulfonyl chloride to give N-p-tolylsulfonyl-2,2′- and 2,3′-dipyridylamines, respectively, as a result of reductive acylamination. In the reactions with 4-aminopyridine and 4-p-tolylsulfonyl- aminopyridine, their N-p-tolylsulfonyl- and N,N-bis(p-tolylsulfonyl) derivatives are formed, while reductive acylamination does not occur. 2005 Pleiades Publishing, Inc.
- Solekhova,Kurbatov
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p. 128 - 130
(2007/10/03)
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- Reductive amination of quinoline N-oxide with aminopyridines and their N-tozyl derivatives
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In reaction of quinoline N-oxide with 2-aminopyridine in the presence of tosyl chloride the substrate undergoes reductive amination into 2-pyridyl(2-quinolyl)amine, and with 3- and 4-aminopyridines reductive tosylamination occurs to furnish N-tosyl derivatives of the corresponding 3- and 4-pyridyl(2-quinolyl)amines. N-tosyl derivatives of aminopyridines also react along reductive tosylamination pathway.
- Solekhova,Kurbatov
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p. 1192 - 1194
(2007/10/03)
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