- Synthesis of trimethylammoniumphenylthio-substituted phthalocyanines with different pattern of substitution
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The base-catalyzed cyclotetramerization of 3-, 4- and 4,5-dimethylaminophenylthio phthalonitriles with zinc(II)acetate afforded 1(4),8(11),15(18),22(25)- and 2(3),9(10),16(17),23(24)-tetrasubstituted and 2,3,9,10,16,17,23,24-octasubstituted Zn(II)phthalocyanines, respectively. The statistical mixed condensation of the same phthalonitriles with 1,2-dicyanobenzene gave the corresponding mono- and disubstituted derivatives. Methylation of such products afforded a series of cationic Zn(II)phthalocyanines with different pattern of substitution, with potential use as photodynamic agents in microbial infections.
- Giuntini, Francesca,Nistri, Daniele,Chiti, Giacomo,Fantetti, Lia,Jori, Giulio,Roncucci, Gabrio
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p. 515 - 517
(2007/10/03)
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