- Bromometric assay of hydrocodone and hydromorphone
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Hydrocodone reacts with bromine to yield the 1-bromo; 1,7α- and 1,7β-dibromo or 1,7,7-tribromo compounds, respectively, while 1- and 2-bromo; 1,2-, 1,7- and 2,7-dibromo or otherwise 1,2,7β-tribromo derivatives are obtained from hydromorphone. Anellated thiazoles are achieved by the reaction of the α-bromo ketones with thiourea.
- Gorlitzer,Schumann
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