- Azole-N-acetonitriles as carbonyl synthons: A one-pot preparation of heteroaryl amides from halides
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Azole-N-acetonitrile derivatives were utilized as synthons for an ambident carbonyl moiety via a strategy relying upon sequential base-mediated S NAr substitution of a 2-halo heterocycle, in situ oxidation, and amine displacement. This strategy allows prompt and efficient synthesis of N-containing heteroaryl amides directly from the corresponding halides via a one-pot process.
- Zhang, Zhongxing,Yin, Zhiwei,Kadow, John F.,Meanwell, Nicholas A.,Wang, Tao
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p. 2323 - 2326
(2007/10/03)
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- Polycyclic N-Hetero Compounds. XXII. . Reaction of Pyridine N-oxides and Pyrazino Di-N-Oxides with Formamide
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Reactions of pyridine N-oxides, pyrazine N-oxides and their benzologues with formamide are described.Carbamoylation mainly occured at aromatic ring with loss of the N-oxide oxygen atom, however, 2,4,6-trimethylpyridine 1-oxide gave 2- and 4-pyrimidinyl derivatives.
- Hirota, Takashi,Namba, Tetsuto,Sasaki, Kenji
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p. 949 - 953
(2007/10/02)
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