Radical Heterocyclization and Heterocyclization Cascades Triggered by Electron Transfer to Amide-Type Carbonyl Compounds
Radical heterocyclizations triggered by electron transfer to amide-type carbonyls, using SmI2-H2O, provide straightforward access to bicyclic heterocyclic scaffolds containing bridgehead nitrogen centers. Furthermore, the first radical heterocyclization cascade triggered by reduction of amide-type carbonyls delivers novel, complex tetracyclic architectures containing five contiguous stereocenters with excellent diastereocontrol.
Huang, Huan-Ming,Procter, David J.
supporting information
p. 14262 - 14266
(2017/10/20)
Design and synthesis of spiro-heterocycles by ring-closing metathesis
Synthesis of diverse spiro-heterocyclic compounds via the ring-closing (RCM) metathesis approach is described. Specifically, synthesis of various derivatives of barbituric acid, Meldrum's acid, tetronic acid and thiotetronic acid are described by RCM approach.
Kotha, Sambasivarao,Deb, Ashoke Chandra
p. 1120 - 1134
(2008/12/23)
Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction
Barbituric acid 1 and related β-dicarbonyl compounds were dialkenylated under the phase-transfer catalyst [e.g., benzyltriethylammonium chloride (BTEAC)] conditions to generate the diallylated products. These diallylated products were subjected to the ring-closing metathesis (RCM) reaction to deliver the corresponding spiro-annulated derivatives.