Novel imidazoles of the formula STR1 and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
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(2008/06/13)
Synthesis and pharmacological properties of N-thienyl alkylenediamines
A series of N-thienylalkylenediamines was synthesized and tested for their analgesic, anti-inflammatory and anti-pyretic activities, as well as for their acute toxicity and central effects.Acetylsalicylic acid, phenylbutazone and indomethacin were used as reference drugs.Several compounds showed interesting aspirin-like properties associated with good systemic and gastric tolerance.Keywords: 2-nitrothiophenes / N-thienyl alkylenediamines / anti-inflammatory activity / analgesic activity / basic anti-inflammatory agents
Ronsisvalle, Giuseppe,Pappalardo, Maria S.,Vittorio, Franco,Pasquinucci, Lorella,Caruso, Antonina,et al.
p. 553 - 560
(2007/10/02)
Alkylaminonitrobenzenes by Vicarious Nucleophilic Amination with 4-(Alkylamino)-1,2,4-triazoles
A series of 4-(alkylamino)-1,2,4-triazoles transfer the alkylamino group to the 4-position of nitrobenzene and various 3-substituted nitrobenzenes, with no detectable ortho substitution.By contrast 2-nitrothiophene reacts in the 3-position and 2-nitronaphthalene in the 1-position; 1-nitronaphthalene gives a mixture of products derived from dominant 2- with some 4-substitution.The orientations are discussed and rationalized.
Katritzky, Alan R.,Laurenzo, Kathleen S.
p. 3978 - 3982
(2007/10/02)
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