cas 5228-48-8, 2-METHYL-5-NITRO-2H-INDAZOLE

Articles about 5228-48-8Total 11 be found

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New nitroindazolylacetonitriles: Efficient synthetic access: Via vicarious nucleophilic substitution and tautomeric switching mediated by anions
New N-Alkyl-nitroindazolylacetonitriles were efficiently obtained via vicarious nucleophilic substitution of N-methyl-nitroindazoles with 4-chlorophenoxyacetonitrile. All compounds were fully characterized by NMR and mass spectroscopy techniques and the structures of some of them were additionally confirmed by X-ray diffraction analysis data. Tautomeric switching was observed in this series of nitroindazolylacetonitriles upon addition of basic anions followed by UV-Vis spectrophotometric and 1H-NMR titrations. The formation of tautomeric species induced by anionic species was endorsed by Density Functional Theory calculations.
Eddahmi, Mohammed,Moura, Nuno M. M.,Bouissane, Latifa,Gamouh, Ahmed,Faustino, Maria A. F.,Cavaleiro, José A. S.,Paz, Filipe A. A.,Mendes, Ricardo F.,Lodeiro, Carlos,Santos, Sérgio M.,Neves, Maria G. P. M. S.,Rakib, El Mostapha
p. 14355 - 14367
(2019/09/30)

INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compou
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Paragraph 00146

(2016/01/25)

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.
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Paragraph 000406

(2016/05/02)

SnCl2/EtOH-mediated Synthesis of Novel 4-Ethoxy-and 4-Chloroindazoles Bearing Sulfonamide Moieties
The treatment of N-alkyl-5-nitroindazole with stannous chloride in ethanol, aftercoupling of the obtained amines with arylsulfonyl chloride in pyridine, gave the new 4-ethoxy-and 4-chloroindazoles bearing sulfonamide in moderate to good yields. Chlorinati
Chicha, Hakima,Bouissane, Latifa,El Ammari, Lahcen,Saadi, Mohamed,Baltas, Michel,El Mostapha, Rakib
supporting information
p. 2005 - 2013
(2015/08/18)

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.
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Paragraph 0659; 0668

(2015/01/06)

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases
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Page/Page column 94; 95; 96

(2013/07/19)

Regioselective methylation of indazoles using methyl 2,2,2- trichloromethylacetimidate
An efficient and regio selective synthesis of substituted 2-methyl-2H-indazoles using a methyl 2,2,2-trichloroacetimidate is described.
Baddam, Sudhakar Reddy,Uday Kumar,Panasa Reddy,Bandichhor, Rakeshwar
supporting information
p. 1661 - 1663
(2013/03/29)

An expedient, regioselective synthesis of novel 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]- and -[4,5-g]indazoles and their anticancer potential
Several novel 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]- and -[4,5-g]indazoles and their 6-alkyl and 8-alkyl derivatives have been synthesised in high overall yields starting from 5-nitro and 6-nitroindazoles in a three-step route involving the regioselective cyclisation of thioureidoindazoles and indazolyl dithiocarbamates as the key steps. Some assorted thiazoloindazoles have been screened for anticancer properties, which demonstrated the anticancer potential of at least one product, justifying its further follow-up.
Chakrabarty, Manas,Kundu, Taraknath,Arima, Shiho,Harigaya, Yoshihiro
p. 6711 - 6723
(2008/12/20)

Reduction of nitroindazoles: Preparation of new amino and chloroamino derivatives
The synthesis of chloroaminoindazoles by the reduction of the nitro group of indazoles using stannous chloride in alcoholic acid solution is reported. Using catalytic hydrogenation with palladium the expected reduction to amino-indazoles occur.{A figure is presented}. Indazole Nitro Reduction Chlorination Aminochloroindazole Heterocycle.
Miloudi, Abdellah,El Abed, Douniazed,Boyer, Gerard,Galy, Jean-Pierre
p. 2595 - 2605
(2008/02/04)

Efficient and regioselective synthesis of 2-alkyl-2H-indazoles
An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium hexafluorophosphate is reported.
Cheung, Mui,Boloor, Amogh,Stafford, Jeffrey A.
p. 4093 - 4095
(2007/10/03)

Synthesis of Pyrazoloacridin-9(10H)-ones
Eight pyrazoloacridin-9(10H)-ones were prepared in a three step procedure from 5- and 6-nitroindazoles.Palladium catalysed hydrogenation of nitroindazoles afforded the corresponding 5- and 6-aminoindazoles.These, in turn, reacted with o-chlorobenzoic acid under the conditions of the Ullman reaction to give anthranilic acids.Cyclisation of these acids by means of sulfuric acid led to the title compounds.If phosphoryl chloride was used, instead of sulfuric acid, a 9-chloroacridine derivative was obtained.All the compounds were characterised by 1H NMR spectroscopy.
Boyer, Gerard,Galy, Jean-Pierre,Faure, Robert,Elguero, Jose,Barbe, Jacques
p. 2601 - 2615
(2007/10/02)

Chemical Properties

Melting Point: 129-131°C
Boiling Point: 364.5°Cat760mmHg
Flash Point:174.2°C
Density: 1.42g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 0mmHg at 25°C
BRN: 167044
PSA: 63.64000
LogP: 2.00470

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5228-48-8

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Chemical Properties

Melting Point: 129-131°C

Boiling Point: 364.5°Cat760mmHg

Flash Point:174.2°C

Density: 1.42g/cm³

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 0mmHg at 25°C

BRN: 167044

PSA: 63.64000

LogP: 2.00470

Global suppliers and manufacturers of 5228-48-8total 41 suppliers on LookChem

Article Database

5228-48-8

Articles about 5228-48-8Total 11 be found

More Articles about upstream products of 5228-48-8

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Chemical Properties

Melting Point: 129-131°C

Boiling Point: 364.5°Cat760mmHg

Flash Point:174.2°C

Density: 1.42g/cm3

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 0mmHg at 25°C

BRN: 167044

PSA: 63.64000

LogP: 2.00470

Global suppliers and manufacturers of 5228-48-8total 41 suppliers on LookChem

Density: 1.42g/cm³