- 4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
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- Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains
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The synthesis of novel 1β-methylcarbapenems 1a,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative 1a exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem.
- Kang, Yong Koo,Lee, Kyung Seok,Yoo, Kyung Ho,Shin, Kye Jung,Kim, Dong Chan,Lee, Chang-Seok,Kong, Jae Yang,Kim, Dong Jin
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p. 463 - 466
(2007/10/03)
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