Stereoselective synthesis of trans-2,3-disubstituted pyrrolidines via addition to N-acyliminium ions
An efficient and stereoselective synthesis of trans-2,3-disubstituted pyrrolidines is described. The intermolecular alkylation of racemic N-acyliminium ions generated in situ from the corresponding 3-substituted lactams proceeds stereoselectively and in h
Convergent Synthesis of Pyrrolidines, Piperidines, Perhydroazepines and Tetrahydroisoquinolines via Zirconocene η2-Imine Complexes
Zirconocene η2-imine complexes formed by a C-H activation route from a variety of amines are trapped by ω-halo-alkenes or -alkynes to afford 2,3-disubstituted pyrrolidines, piperidines and perhydroazepines on work up and cyclisation.In some cas
Harris, Michael C. J.,Whitby, Richard J.,Blagg, Julian
p. 4287 - 4290
(2007/10/02)
A General Stereocontrolled Synthesis of cis-2,3 Disubstituted Pyrrolidines and Piperidines
A general synthetic method is reported for the preparation of cis-2,3-disubstituted pyrrolidines and piperidines from readily available acyclic precursors.The key reaction involves the stereoselective reduction of a cyclic imine controlled by the C-3 subs
Pal, Kollol,Behnke, Mark L.,Tong, Liang
p. 6205 - 6208
(2007/10/02)
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