- Some Extensions of von Braun (BrCN) Reaction on Organic Bases: Part II
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Extensions of von Braun Cyanogen bromide reaction on Ephedra alkaloids and simpler bases have resulted in synthesis of substituted oxazolidines and a whole series of nitrogen analogues of ephedrine, desoxy ephedrine and simpler amines.The general applicability and limitations of such extension of the reaction are also discussed. - Key words: von Braun Cyanogen Bromide Reaction
- Malik, Abdul,Afza, Nighat,Siddiqui, Salimuzzaman
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p. 512 - 518
(2007/10/02)
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- Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
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Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenylalkylamines and phenylalkylureas having the formula: STR1 wherein Z is selected from the group consisting of --NHR2 or STR2 and R is selected from the group consisting of hydrogen, halogen, lower-alkoxy and trifluoromethyl and R1, R2, R3 and R4 are selected from the group consisting of hydrogen and lower-alkyl, where R3 and R4 taken together with the adjacent nitrogen atom may form a heterocyclic ring selected from the group of piperidino, pyrrolidino, piperazino, and morpholino.
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