Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
The global emergence of antibiotic resistance is one of the most serious challenges facing modern medicine. There is an urgent need for validation of new drug targets and the development of small molecules with novel mechanisms of action. We therefore sou
Lim, Carine S.Q.,Ha, Kam Pou,Clarke, Rebecca S.,Gavin, Leigh-Anne,Cook, Declan T.,Hutton, Jennie A.,Sutherell, Charlotte L.,Edwards, Andrew M.,Evans, Lindsay E.,Tate, Edward W.,Lanyon-Hogg, Thomas
(2019/07/16)
Developing ciprofloxacin analogues against plant DNA gyrase: A novel herbicide mode of action
Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.
Wallace, Michael D.,Waraich, Nidda F.,Debowski, Aleksandra W.,Corral, Maxime G.,Maxwell, Anthony,Mylne, Joshua S.,Stubbs, Keith A.
supporting information
p. 1869 - 1872
(2018/02/23)
NOVEL 14 AND 15 MEMBERED-RING COMPOUNDS
The present invention relates to 15-membered macrolides substituted at the 4" position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
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Page 32-33
(2010/02/09)
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