- Defect Engineering into Metal-Organic Frameworks for the Rapid and Sequential Installation of Functionalities
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Postsynthetic treatments are well-known and important functionalization tools of metal-organic frameworks (MOFs). Herein, we have developed a practical and rapid postsynthetic ligand exchange (PSE) strategy using a defect-controlled MOF. An increase in the number of defects amounts to MOFs with enhanced rates of ligand exchange in a shorter time frame. An almost quantitative exchange was achieved by using the most defective MOFs. This PSE strategy is a straightforward method to introduce a functionality into MOFs including bulky or catalytically relevant moieties. Furthermore, some mechanistic insights into PSE were revealed, allowing for a sequential ligand exchange and the development of multifunctional MOFs with controlled ligand ratios.
- Park, Hyojin,Kim, Seongwoo,Jung, Byunghyuck,Park, Myung Hwan,Kim, Youngjo,Kim, Min
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supporting information
p. 1040 - 1047
(2018/02/14)
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- 2-amino-4-methanesulfonamide preparation of methyl benzoic acid methyl ester
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The invention relates to a method for preparing 2-amino-4-methanesulfonamide methylbenzoate. According to the method, dimethyl terephthalate serves as a raw material, and then 2-amino-4-methanesulfonamide methylbenzoate is prepared through nitrification, ammonolysis, dehydration, hydrogenation reduction and sulfonylation. The method has the advantages that the raw material is easy to obtain, the reaction conditions are mild, the yield is high, the byproducts are few, the pollution is little, and the like; the difficult problems in the existing mesosulfuron-methyl preparation processes that the raw material is expensive, the conditions are harsh, the pollution is serious, and the like are solved effectively.
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Paragraph 0029; 0030; 0031
(2017/02/09)
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- Compound a preparation UNC1215 method
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The invention discloses a method for preparing a compound UNC1215, belonging to the technical field of pharmaceutical chemistry synthesis. The method sequentially comprises the following steps: nitration, nitro reduction reaction, Buchwald reaction, esterolysis reaction, condensation reaction and the like. The overall reaction yield can reach 67%, which is higher than the yield (60%) in the document. The method changes the synthesis route, avoids the pipe sealing reaction, sequentially performs the nitration, reduction reaction, Buchwald reaction, hydrolysis reaction and condensation reaction, and is simple to operate.
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Paragraph 0031-0033
(2017/03/14)
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- Selective fluorescence sensing of cyanide with an o-(carboxamido)trifluoroacetophenone fused with a cyano-1,2-diphenylethylene fluorophore
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A novel fluorescence probe has been synthesized, which consists of o-(carboxamido)trifluoroacetophenone moiety as the recognition element and cyano-1,2-diphenylethylene moiety as the signaling unit. Fluorescence titrations of the probe with anions such as F-, Cl-, I-, CN-, SCN-, AcO-, H2 PO4-, HSO4-, and ClO4- as their Bu4N+ salts in acetonitrile show that CN- is the most efficient quencher, AcO- and F- follow it, and other anions show little changes. In an aqueous medium, MeOH-water (9:1), the probe shows fluorescence quenching only toward cyanide and no changes toward the other anions.
- Lee, Hanna,Chung, Yun Mi,Ahn, Kyo Han
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p. 5544 - 5547
(2008/12/22)
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- Synthesis and photophysical studies of bis-enediynes as tunable fluorophores
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We have synthesized a family of bis-enediynes by two complementary Pd/Cu-catalyzed Sonogashira cross-coupling methods. One is a modified Sonogashira reaction between the TMS-protected tetraalkyne 20 (or 21) and various aromatic bromides to afford bis-enediynes 22a-d and 23a-d bearing different peripheral aryl units. The other, the reaction of bifunctional 1,1-dibromo-1-alkenes with phenylacetylene, afforded a series of bis-enediynes 24-32 bearing various core aryl groups. These chemical modifications to the core and periphery of bis-enediynes induce dramatic changes in absorption and emission spectra. Bis-enediynes 22 and 23 show a large Stokes shift of about 50-110 nm when compared to the less-conjugated bis-enediynes 20 and 21. Absorptions and emissions of bis-enediynes 25, 27-29, and 31 were red-shifted relative to those of enediyne 35. Substantial increases in fluorescence quantum yields are observed as a result of extending the π-conjugation. The emission wavelength of bis-enediynes was tailored from indigo blue to reddish-orange, suggesting that the color of emission can be tunable by modification of the core and/or peripheral units.
- Hwang, Gil Tae,Son, Hyung Su,Ku, Ja Kang,Kim, Byeang Hyean
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p. 11241 - 11248
(2007/10/03)
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- Nonacid nitration of benzenedicarboxylic and naphthalenecarboxylic acid esters
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When treated with nitrogen dioxide in the presence of ozone and a catalytic amount of iron(III) chloride in inert organic solvent at -10 to +5 °C, benzenedicarboxylic acid diesters 1, 4, and 6 underwent smooth nitration to give the corresponding mononitro derivatives 2/3, 5, and 7, respectively, in good yield (kyodai nitration). Naphthalenecarboxylic acid esters 8 and 11 and naphthalene-1,8-dicarboxylic acid diester 16 were similarly nitrated in the absence of catalyst to give the expected nitro compounds 9/10, 12-15, and 17-22, respectively. Different from conventional nitration based on the combined use of concentrated nitric and sulfuric acids, no hydrolytic cleavage of the ester function was observed under these conditions. The isomer distribution has been determined for the nitration of naphthalenecarboxylic acid esters 8, 11, and 16, and spectral data were collected for less common nitro derivatives. A unique changeover of the orientation mode observed in the kyodai nitration of diester 16, from the initial exclusive meta to the final meta/para, has been discussed in terms of the competition between the electrophilic substitution process involving the nitronium ion (NO2+) and the addition-elimination sequence involving the nitrogen trioxide radical (NO3).
- Nose,Suzuki,Suzuki
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p. 4356 - 4360
(2007/10/03)
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- Nonproteinogenic Amino Acids, IV. - EPC Synthesis of L-(+)-Forphenicine
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Enantiomerically pure L-(+)-forphenicine (12) is synthesized starting from purchasable 3-methoxybenzaldehyde (1) by the use of (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (2) as a chiral auxiliary and prussic acid. 12 is identical with the natural product which has been isolated from the culture broth of an Actinomyces species and which is known to be a potent inhibitor of alkaline phosphatase.
- Weinges, Klaus,Reinel, Ute,Maurer, Wolfgang,Gaessler, Norbert
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p. 833 - 838
(2007/10/02)
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- Agricultural sulfonamides
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This invention relates to novel N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted by two carboxyl radicals. The compounds have utility as herbicides.
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- 6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-carboxaldehyde
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This invention relates to a novel method for the preparation of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid and the novel intermediate 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-carboxaldehyde used in the preparation thereof.
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