- NEW TRPA1 ANTAGONISTS
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The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.
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Page/Page column 46; 47
(2017/05/02)
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- NEW TRPA1 ANTAGONISTS
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The present invention relates to compounds of Formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.
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Page/Page column 68
(2017/08/01)
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- Synthesis and Reactivity of 2,6-Diamino-4-methyl-3-pyridinecarbonitrile
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2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile is converted via its 2,6-dichloro analog into the corresponding 2-amino-6-chloro, 2-chloro-6-amino, and 2,6-diamino derivatives.The last reacts with benzenesulfonyl chloride to yield a tris-sulfonyl derivative, the structure of which is demonstrated by X-ray analysis.
- Katritzky, Alan R.,Rachwal, Stanislaw,Smith, Terrance P.,Steel, Peter J.
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p. 979 - 984
(2007/10/02)
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