- Intermediate for synthesis of desogestrel and preparation method thereof
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The invention relates to a steroid compound and application of the same to preparation of a desogestrel intermediate, i.e., 13-ethylsterane-3,11,17-trione. The novel compound is prepared through oxidation, transposition, hydroboration-oxidation, ketalization and a lithium-ammonia reaction of starting materials; and then 13-ethylsterane-3,11,17-trione is prepared by using the compound, and the preparation process is simple, easily practicable, environment-friendly, high in yield, and suitable for industrial production.
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- PROCESS FOR THE SELECTIVE ISOLATION, PURIFICATION AND SEPARATION OF MONOHYDROXYLATED 3,17-DIKETO-STEROID COMPOUNDS
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The subject of the present invention is a new process for the selective isolation, purification and separation of monohydroxylated 3,17-diketo-steroid compounds from a solution obtained preferably by microbiological way containing a mixture of steroid compounds via selective extraction, purification and selective crystallization of the steroid compounds by treatment of several solvents.
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Page/Page column 12-14
(2008/06/13)
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