- Supported palladium oxide nanoparticles in Al-SBA-15 as an efficient and reusable catalyst for the synthesis of pyranopyrazole and benzylpyrazolyl coumarin derivatives via multicomponent reactions
-
An eco-friendly method for diversity-oriented synthesis of substituted dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been achieved via one-pot and multicomponent reaction in the presence of PdO/Al-SBA-15 as an efficient and rec
- Heravi, Majid M.,Malakooti, Reihaneh,Kafshdarzadeh, Kosar,Amiri, Zahra,Zadsirjan, Vahideh,Atashin, Hassan
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p. 203 - 234
(2022/01/19)
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- Tungstic acid (H4WO5) immobilized on magnetic-based zirconium amino acid metal–organic framework: An efficient heterogeneous Br?nsted acid catalyst for l-(4-phenyl)-2,4-dihydropyrano[2,3c]pyrazole derivatives preparation
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A new magnetic nanocatalyst based on the immobilization of tungstic acid onto new design robust, cost-effective, green, and scalable zirconium-L-aspartate amino acid metal–organic framework (MOF)-grafted L-(+)-tartaric acid stabilized magnetite nanopartic
- Khademi, Shima,Zahmatkesh, Saeed,Aghili, Alireza,Badri, Rashid
-
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- Sugarcane Bagasse Ash-Based Silica-Supported Boric Acid (SBA-SiO2-H3BO3): A Versatile and Reusable Catalyst for the Synthesis of 1,4Dihydropyrano[2,3c]pyrazole Derivatives
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Abstract: A simple, green, and efficient protocol has been developed for the synthesis of biologically active 1,4dihydropyrano[2,3c]pyrazole derivatives via one-pot four-component reaction of various substituted benzaldehydes, hydrazine hydrate or phenylh
- Kumar, A.,Pandey, A. K.,Shrivastava, S. C.
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p. 653 - 660
(2021/06/02)
-
- Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities
-
A convenient and eco-friendly, one-pot synthetic protocol for pharmaceutically important pyran-based heterocyclic compounds is repeated herein. The reactions were carried out at room temperature in a water–ethanol solvent mixture under direct irradiation
- Dutta, Arup,Rahman, Noimur,Kumar, John Elisa,Rabha, Jintu,Phukan, Tridip,Nongkhlaw, Rishanlang
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supporting information
p. 263 - 278
(2020/11/03)
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- Synthesis, characterization and application of Fe3O4@SiO2@CPTMO@DEA-SO3H nanoparticles supported on bentonite nanoclay as a magnetic catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles
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Fe3O4 nanoparticles were prepared and decorated on the surface of nanobentonite (NB), and subsequently modified by the organic and inorganic linkers and then sulfonic acid immobilization on the nanoparticles. The NB-Fe3Os
- Eftekhari far, Behrouz,Nasr-Esfahani, Masoud
-
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- Sulfonic acid-functionalized Fe3O4-supported magnetized graphene oxide quantum dots: A novel organic-inorganic nanocomposite as an efficient and recyclable nanocatalyst for the synthesis of dihydropyrano[2,3-c]pyrazole and 4H-chromen
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In this research, the main emphasis has been focused on the preparation of a novel Fe3O4-supported propane-1-sulfonic acid-grafted graphene oxide quantum dots (Fe3O4@GOQD-O-(propane-1-sulfonic acid)) that it was
- Khaleghi Abbasabadi, Masoud,Azarifar, Davood,Esmaili Zand, Hamid Reza
-
-
- Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors
-
The design and synthesis of novel pyrazole based derivatives has been carried out using the ligand based approach like pharmacophore and QSAR modelling of reported pyrazoles from the available literature to investigate the chemical features that are essential for the design of selective and potent COX-2 inhibitors. Both pharmacophore and QSAR models with good statistical parameters were selected for the design of the lead molecule. Also by exploiting the chemical structures of selective and marketed COX-2 inhibitors, celecoxib and SC-558 were used in designing the molecules which are used in the treatment of inflammation and related disorders. The therapeutic action of the Non-Steroidal Anti-inflammatory Agents (NSAIDs) is based primarily on the COX-2 inhibition. With this background we have synthesized some azomethine derivatives of 3-methyl-1-substituted-4-phenyl-6-[{(1E)-phenylmethylene}amino]-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile 6(a-o) and were characterized by 1HNMR, 13CNMR and Mass spectral techniques. All the synthesized pyrazole derivatives were tested for in vitro membrane stability property in both COX-1 & COX-2 inhibition studies and in vivo anti-inflammatory activity by carrageenan induced rat paw edema model. Among them, compound 6k showed very good activity by in vivo anti-inflammatory activity with 0.8575 mmol/kg as ED50. Similarly compounds 6m, 6o, 6i and 6h exhibited comparable anti-inflammatory activity to standard drugs. Also the active compounds were further screened for ulcerogenic activity and were found be safer with less ulcer index compared to the marketed drugs like aspirin, ibuprofen and celecoxib.
- Murahari, Manikanta,Mahajan, Vivek,Neeladri, Sreenivasulu,Kumar, Maushmi S.,Mayur
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p. 583 - 597
(2019/02/24)
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- Application of Yttrium Iron Garnet as a Powerful and Recyclable Nanocatalyst for One-Pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives under Solvent-Free Conditions
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The application of yttrium iron garnet (YIG) superparamagnetic nanoparticles as a new recyclable and highly efficient heterogeneous magnetic catalyst for one-pot synthesis of pyrano[2,3-c]pyrazole derivatives under solvent-free conditions, as well as etherification and esterification reactions are described. The advantages of the proposed method include the lack of organic solvents, clean reaction, rapid removal of the catalyst, short reaction times, excellent yields, and recyclability of the catalyst.
- Sedighinia,Badri,Kiasat
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p. 1755 - 1763
(2020/01/11)
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- An Eco-friendly Catalytic System for One-pot Multicomponent Synthesis of Diverse and Densely Functionalized Pyranopyrazole and Benzochromene Derivatives
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An external base-free, efficient, cost-effective, and environmentally benign protocol has been developed for the one-pot multicomponent synthesis of highly functionalized pyranopyrazoles and benzochromenes using water extract of Agave americana (century p
- Patil,Patil, Rupesh C.,Patil, Suresh S.
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- Fe3O4-supported N-pyridin-4-amine-grafted graphene oxide as efficient and magnetically separable novel nanocatalyst for green synthesis of 4H-chromenes and dihydropyrano[2,3-c]pyrazole derivatives in water
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Abstract: Fe3O4-magnetized N-pyridin-4-amine-functionalized graphene oxide [Fe3O4@GO-N-(pyridin-4-amine)] was readily prepared via a three-step procedure. The synthesized nanofilms were characterized by scanning
- Azarifar, Davood,Khaleghi-Abbasabadi, Masoud
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p. 199 - 222
(2018/10/15)
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- Preparation, characterization and catalytic application of molybdenum Schiff-base complex immobilized on silica-coated Fe3O4 as a reusable catalyst for the synthesis of pyranopyrazole derivatives
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A recoverable molybdenum Schiff-base complex immobilized on silica-coated Fe3O4 nanoparticles was prepared and characterized. This superparamagntic nanocatalyst, which is separable using an external magnet, can be used as an efficien
- Hamrahian, Seyedeh Aghigh,Salehzadeh, Sadegh,Rakhtshah, Jamshid,Haji babaei, Farshid,Karami, Niloofar
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- A concise route for the one-pot multi-component synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles and pyranopyrazoles using cobalt (II) nitrate hexahydrate as catalyst
-
Three facile and efficient routes for one-pot, cobalt (II) nitrate hexahydrate catalyzed multi-component synthesis of 2-amino-3-cyanopyridine and pyranopyrazole derivatives have been developed. The present protocols offer the products in good yields from the simple and readily available starting materials. The other salient features of these protocols are operational simplicity, easy isolation of product without the need of column chromatographic purification, and the use of cobalt (II) nitrate hexahydrate as an efficient catalyst.
- Pejman, Hamed,Hazeri, Nourallah,Fatahpour, Maryam,Faroughi Niya, Homayoun
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p. 241 - 247
(2019/07/31)
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- Environmentally benign synthesis of pyranopyrazole derivatives by cobalt Schiff-base complexes immobilized on magnetic iron oxide nanoparticles
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In this work, an efficient and straight procedure has been described for one-pot three-component synthesis of pyranopyrazole derivatives in the presence of a new cobalt Schiff-base complex immobilized on silica-coated Fe3O4 nanoparti
- Shaabani, Behrouz,Maleki, Hossein,Rakhtshah, Jamshid
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p. 139 - 147
(2019/07/10)
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- Zn(L-proline)2 as an efficient and reusable catalyst for the multi-component synthesis of pyran-annulated heterocyclic compounds
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We have developed a simple, straightforward and highly efficient multi-component one-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocyclic compounds. Zn(L-proline)2 has been utilized as a mild and efficient Lewis acid cata
- Tahmassebi, Daryoush,Blevins, John E.,Gerardot, Shori S.
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- SBA-Pr-NH2 catalyzed preparation of pyrano[2, 3-c]pyrazoles under solvent-free conditions
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This report provides a description of an efficient and simple procedure for the synthesis of pyrano[2, 3-c]pyrazole derivatives via a one-pot three-component reaction of arylmethylidene malononitrile, ethylacetoacetate and phenylhydrazine in the presence of amino-functionalized SBA-15 as a highly effective heterogeneous solid basic catalyst under solvent-free conditions. The remarkable advantages are the simplicity of the experimental procedures, high yields, short reaction times, and reusability of the catalyst.
- Zainali, Mahnaz,Amrollahi, Mohammad A.
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- A ternary hybrid system based on combination of mesoporous silica, heteropolyacid and double-layered clay: an efficient catalyst for the synthesis of 2,4-dihydro-3H-pyrazol-3-ones and pyranopyrazoles in aqueous medium: studying the effect of the synthetic
-
SBA/hydrotalcite/heteropolyacid nanocomposite is synthesized via a novel procedure in which the as-prepared heteropolyacid-loaded SBA-15 was impregnated with calcined hydrotalcite. The ternary hybrid system was characterized by using SEM/EDS, XRD, BET, TP
- Sadjadi, Samahe,Heravi, Majid M.,Zadsirjan, Vahideh,Farzaneh, Vahid
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p. 6765 - 6785
(2018/07/13)
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- NaF-catalyzed efficient one-pot synthesis of dihydropyrano[2,3-c]pyrazoles under ultrasonic irradiation via MCR approach
-
Sodium fluoride was identified as an efficient catalyst for the preparation of series of dihydropyrano [2,3-c]pyrazoles (4a–l) by the three-component condensation of 3-Methyl-1-phenyl-2-pyrazoline-5-one (1), aromatic aldehydes (2) and malononitrile (3) in
- Konakanchi, Ramaiah,Gondru, Ramesh,Nishtala, Venkata Bharat,Kotha, Laxma Reddy
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p. 1994 - 2001
(2018/07/03)
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- Synthesis and antimicrobial screening of pyrimidine annulated dihydropyrano[2, 3-c] pyrazole derivatives
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A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction
- Hegde, Hemant,Ahn, Chuljin,Waribam, Preeti,Shetty, Nitinkumar S.
-
-
- Amino acid ionic liquid-based titanomagnetite nanoparticles: An efficient and green nanocatalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles
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The amino acid ionic liquid tetrabutylammonium asparaginate (TBAAsp) was immobilized on titanomagnetite (Fe3?xTixO4) nanoparticles in a facile one-pot process using an organosilane compound (TMSP) as spacer. The modified F
- Azarifar, Davood,Badalkhani, Omolbanin,Abbasi, Younes
-
-
- Zn(ANA)2Cl2 complex as efficient catalyst for the synthesis of dihydropyrano[2,3-c]pyrazoles in aqueous medium via one-pot multicomponent reaction: a green approach
-
The first example of recyclable Zn(ANA)2Cl2 catalyzed tandem one-pot three-component protocol reaction between aromatic aldehydes, malononitrile, and phenylmethylpyrazolone to furnish 4-substituted-1,4-dihydropyrano[2,3-c]pyrazole-5-
- Konakanchi, Ramaiah,Nishtala, Venkata Bharat,Kankala, Shravankumar,Kotha, Laxma Reddy
-
supporting information
p. 2642 - 2651
(2018/11/26)
-
- Tungstic acid-functionalized Fe3O4@TiO2: preparation, characterization and its application for the synthesis of pyrano[2,3-c]pyrazole derivatives as a reusable magnetic nanocatalyst
-
A new magnetic nanocatalyst based on the immobilization of tungstic acid onto 3-chloropropyl-grafted TiO2-coated Fe3O4 nanoparticles (Fe3O4@TiO2@(CH2)3OWO3H
- Gholtash, Jamileh Etemad,Farahi, Mahnaz
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p. 40962 - 40967
(2019/01/03)
-
- One-pot three-component process for the synthesis of substituted pyrano[2,3-c]pyrazoles catalyzed by nanostructured FSM-16-SO3H
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A three-component process for the one-pot synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles by the reaction of aldehydes, 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, and malononitrile in the presence of FSM-16-SO3/s
- Hashemi-Uderji, Somayeh,Abdollahi-Alibeik, Mohammad
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p. 1709 - 1719
(2018/07/06)
-
- Spirocyclopropanes from Intramolecular Cyclopropanation of Pyranopyrazoles and Pyranopyrimidine-diones and Lewis Acid Mediated (3 + 2) Cycloadditions of Spirocyclopropylpyrazolones
-
A robust intramolecular cyclopropanation reaction was first performed on pyranopyrazole and pyranopyrimidine-dione derivatives to obtain spirocyclopropylpyrazolones and barbiturates, using iodosylbenzene (PhIO) or the combination of iodobenzene diacetate (PIDA)/molecular iodine (I2), under mild reaction conditions. Syntheses of functionally and stereochemically diversified, novel spiropyrazolone fused 2-iminothiophene and spiropyrazolone fused pyrroline scaffolds were also demonstrated via Lewis acid catalyzed highly diastereoselective (3 + 2) cycloaddition reactions of the synthesized spiro-cyclopropyl pyrazolones with phenyl isothiocyanate and benzonitrile, respectively.
- Mukherjee, Prasun,Das, Asish R.
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p. 2794 - 2802
(2017/03/14)
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- Synthesis of pyrano[2,3-c]pyrazoles by ionic liquids under green and eco-safe conditions
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Optimization of a green approach to the synthesis of pyrano[2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of se
- Zakeri, Masoumeh,Nasef, Mohamed Mahmoud,Kargaran, Tina,Ahmad, Arshad,Abouzari-Lotf, Ebrahim,Asadi, Jahanbakhsh
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p. 717 - 728
(2017/02/10)
-
- Piperidine-Promoted Three-Component Condensation: Synthesis of Chromene Heterocycles and Pyrazolotriazoles
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Chromenes, the oxygen-containing heterocyclic compounds, have a “special” place in biologically active natural products and in synthetic chemistry and in the fields of medicinal, agrochemical, cosmetic, and pigment industries. In this work, piperidine was used as a base catalyst for the convenient synthesis of 1,4-dihydropyrano[2,3-c]pyrazole, 5,10-dihydro-4H-benzo[g]chromene, and pyrazolo[1,2-a] [1,2,4]triazole derivatives at ambient temperature. This methodology has several advantages including the use of easily accessible and inexpensive catalysts, short reaction times, high yields, convenient work-up, and not needing column chromatography.
- Kangani, Mehrnoush,Hazeri, Nourallah,Yazdani-Elah-Abadi, Afshin,Maghsoodlou, Malek-Taher
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p. 1259 - 1269
(2017/10/18)
-
- Amberlite-supported L-prolinate: A novel heterogeneous organocatalyst for the three-component synthesis of 4H-pyrano[2,3-c]pyrazole derivatives
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This report describes a new and convenient procedure for heterogenization of L-proline organocatalyst, which is based on non-covalent immobilization of L-proline on the surface of anion-exchange resin amberlite IRA900OH (AmbIRA900OH) as an efficient, chea
- Nazari,Keshavarz
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p. 539 - 545
(2017/05/01)
-
- Application of a biological-based nanomagnetic catalyst in the synthesis of bis-pyrazols and pyrano[3,2-c]pyrazoles
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{Fe3O4@SiO2@(CH2)3-thiourea dioxide-SO3H/HCl}, a newly reported nanomagnetic core–shell supported solid acid catalyst, was successfully employed in the preparation of 4,4′-(arylmethylene)bi
- Zolfigol, Mohammad Ali,Navazeni, Mahdiyeh,Yarie, Meysam,Ayazi-Nasrabadi, Roya
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- Ag/Tio2 nano thin films catalyzed efficient synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-C] pyrazole-5-carbonitriles at green conditions
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Ag/TiO2 nano thin films was found to be efficient and green heterogeneous catalyst for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot three-component reaction between 3-methyl-1H-pyrazol-5(4H)-one or 3-methyl-1(phenyl)-
- Irani, Sharmin,Maghsoodlou, Malek Taher,Hadavi, M. Saeed,Hazeri, Nourallah,Lashkari, Mojtaba
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p. 814 - 820
(2017/05/26)
-
- Synthesis of Novel Tacrine Analogs as Acetylcholinesterase Inhibitors
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In this work, a wide range of novel pyrazolo[4′,3′:5,6]pyrano[2,3-b]quinolin-5-amines were synthesized as tacrine analogs. At first, reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, aromatic aldehydes, and malononitrile gave 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles. Then, reaction of the latter compounds with cyclohexanone led to the formation of the title compounds. Also, they were evaluated for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities. Interestingly, most of them showed good inhibitory activity comparing with rivastigmine as the reference drug.
- Mahdavi, Mohammad,Saeedi, Mina,Gholamnia, Laleh,Jeddi, Seyed Amir Behzad,Sabourian, Reyhaneh,Shafiee, Abbas,Foroumadi, Alireza,Akbarzadeh, Tahmineh
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p. 384 - 390
(2017/02/05)
-
- Synthesis of functionalized chromene and spirochromenes using L-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature
-
An efficient and recyclable homogeneous catalyst is developed using commercially cheap L-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, L-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity.
- Nagaraju, Sakkani,Paplal, Banoth,Sathish, Kota,Giri, Santanab,Kashinath, Dhurke
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supporting information
p. 4200 - 4204
(2017/10/06)
-
- ANTI-CANCER COMPOUNDS TARGET RAL GTPASES AND METHODS OF USING THE SAME
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Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
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- Synthesis of novel Ral inhibitors: An in vitro and in vivo study
-
Chemical synthesis was performed to produce a series of 6-amino-1,3-disubstituted-4-phenyl-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile compounds (14–57) which were characterized by1H NMR,13C NMR and LC/MS–MS. These compounds were assessed for their effect on the in vitro anchorage independent growth of human lung cancer cell line H2122 and IC50values calculated. Two of the more potent compounds, BQU057 40 and BQU082 57 also displayed a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay. Mouse PK and tissue distribution studies on 40 and 57 were performed and demonstrated that parent drug was present in tumor 3.0 h post ip (50 mg/Kg) dose.
- Yan, Chao,Theodorescu, Dan,Miller, Bettina,Kumar, Amit,Kumar, Vijay,Ross, David,Wempe, Michael F.
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p. 5815 - 5818
(2016/11/25)
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- Applications of a novel nano magnetic catalyst in the synthesis of 1,8-dioxo-octahydroxanthene and dihydropyrano[2,3-c]pyrazole derivatives
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Imidazole-based ionic liquid-stabilized on silica coated Fe3O4 magnetic nano particles [nano-Fe3O4SiO2(CH2)3-Imidazole-SO3H]Cl as a novel heterogeneous acidic catalyst
- Zolfigol, Mohammad Ali,Ayazi-Nasrabadi, Roya,Baghery, Saeed,Khakyzadeh, Vahid,Azizian, Saeid
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- Aqua-mediated multicomponent synthesis of various 4H-pyran derivatives catalyzed by poly(4-vinylpyridine)-supported copper iodide nanoparticle catalyst
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A green and efficient approach for synthesis of some new 4H-pyran derivatives is reported, catalyzed by green recyclable poly(4-vinylpyridine)-supported copper iodide nanoparticle catalyst in water. This procedure has many advantages such as operational s
- Albadi, Jalal,Mansournezhad, Azam
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p. 5739 - 5752
(2016/06/01)
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- Ultrasound promoted facile one pot synthesis of highly substituted pyran derivatives catalyzed by silica-coated magnetic NiFe2O4 nanoparticle-supported H14[NaP5W30O110] under mild condition
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Silica-coated magnetic NiFe2O4 nanoparticle-supported Preyssler heteropolyacid (H14[NaP5W30O110]) catalyzed efficiently the synthesis of highly substituted pyran derivatives under ultrasoni
- Maleki, Behrooz,Baghayeri, Mehdi,Jannat Abadi, Sedigheh Ayazi,Tayebee, Reza,Khojastehnezhad, Amir
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p. 96644 - 96661
(2016/10/24)
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- Sulfonic acid–functionalized magnetic Fe3-xTixO4nanoparticles: New recyclable heterogeneous catalyst for one-pot synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[2,3-c]pyrazole derivatives
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In this work, titanomagnetite nanoparticles (Fe3-xTixO4) have been used as a novel suppport for the synthesis of a magnetic acidic catalyst. These nanoparticles were functionalized with sulfonic acid groups to prepare the
- Azarifar, Davood,Abbasi, Younes
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p. 745 - 758
(2016/07/06)
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- Silica-coated magnetic NiFe2O4 nanoparticles-supported H3PW12O40; Synthesis, preparation, and application as an efficient, magnetic, green catalyst for one-pot synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-c]pyrazole derivatives
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A powerful, magnetic, supported, acid catalyst, NiFe2O4@SiO2-H3PW12O40, was prepared by chemical support of Keggin (H3PW12O40) heteropolyacid (HPA) on silica-coated NiFe2O4 magnetic nanoparticles. XRD, TEM, SEM, VSM, and FTIR confirmed that the keggin HPA is well dispersed on the surface of silica-coated NiFe2O4 magnetic nanoparticles. The magnetically recoverable catalyst could be easily recycled at least six times without significant loss of catalytic activity. After full characterization, its catalytic activity was investigated in the synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-c]pyrazole derivatives. Graphical Abstract: (1) Novel silica-coated magnetic NiFe2O4 nanoparticles-supported H3PW12O40 was fabricated and characterized. (2) Recyclability of the catalyst. (3) Avoiding use of corrosive acid catalysts. (4) Green chemistry.
- Maleki, Behrooz,Eshghi, Hossein,Barghamadi, Mohammad,Nasiri, Negar,Khojastehnezhad, Amir,Sedigh Ashrafi, Samaneh,Pourshiani, Omid
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p. 3071 - 3093
(2016/04/05)
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- Green synthesis of tetrahydrobenzo[b] pyrans, pyrano[2,3-c] pyrazoles and spiro[indoline-3,4′-pyrano[2,3-c] pyrazoles catalyzed by nano-structured diphosphate in water
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A green and recoverable nano-structured diphosphate (Na2CaP2O7) was synthesized and fully characterized using FT-IR spectra, X-ray diffraction patterns (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray
- Maleki, Behrooz,Nasiri, Negar,Tayebee, Reza,Khojastehnezhad, Amir,Akhlaghi, Hossien Ali
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p. 79128 - 79134
(2016/09/09)
-
- Anti-cancer compounds targeting Ral GTPases and methods of using the same
-
The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
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-
Page/Page column 61; 75
(2016/06/28)
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- One-pot multicomponent synthesis of highly functionalized bio-active pyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives using ZrO2 nanoparticles as a reusable catalyst
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A facile one-pot multicomponent protocol for the synthesis of bio-active pyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been demonstrated using ZrO2 nanoparticles as a catalyst at room temperature. The reactions are very fas
- Saha, Arijit,Payra, Soumen,Banerjee, Subhash
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supporting information
p. 2859 - 2866
(2015/05/27)
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- HClO4-sio2 nanoparticles: An efficient and versatile catalyst for synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles
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The reaction between aromatic aldehydes, malononitrile and 3-methyl-1-phenyl-2-pyrazoline-5-one catalysed by silica supported perchloric acid nanoparticles (HClO4-sio2 nanoparticles) in solvent H2O under reflux provided a
- Sadeghi, Bahareh,Shirkhani, Mona,Hassanabadi, Alireza
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p. 112 - 114
(2015/06/16)
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- Tin sulfide nanoparticles supported on activated carbon as an efficient and reusable Lewis acid catalyst for three-component one-pot synthesis of 4H-pyrano[2,3-c]pyrazole derivatives
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Tin sulfide nanoparticles (SnS-NPs) were prepared in aqueous solution at room temperature on the surface of activated carbon (AC) and were investigated using field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-r
- Iravani, Nasir,Keshavarz, Mosadegh,Shojaeian Kish, Hossein Ali,Parandvar, Rasool
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p. 626 - 633
(2015/09/28)
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- Electro-catalyzed multicomponent transformation of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in green medium
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Abstract An efficient and convenient synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives is described, using the electrogenerated anion of ethanol as the base in the presence of sodium bromide as an supporting electrolyte in a one-pot, three compone
- Vafajoo, Zahra,Hazeri, Nourallah,Maghsoodlou, Malek Taher,Veisi, Hojat
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supporting information
p. 973 - 976
(2015/08/18)
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- BF3 bonded nano Fe3O4 (BF3/MNPs): An efficient magnetically recyclable catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives
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A simple and efficient procedure for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives has been developed by a one-pot three-component reaction of various aldehydes with malononitrile and 3-methyl-1-phenyl-2-pyrazoline-5-one in the presence of
- Abdollahi-Alibeik, Mohammad,Moaddeli, Ali,Masoomi, Kianoosh
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p. 74932 - 74939
(2015/09/21)
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- Covalently supported sulfonic and acetic acids onto polypyrrole asgreen, cheap and recoverablesolid acid catalysts for the synthesis of 4H-pyrano[2,3-c]pyrazoles
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Sulfonated polypyrrole nanospheres and polypyrrole N-functionalized acetic acid were synthesized. The catalytic efficiency of the prepared solid acid catalysts for the synthesis of 4Hpyrano[2,3-c]pyrazoles derivatives was evaluated and compared. The resul
- Fadavipoor, Elham,Nazari, Simin,Ahmadi, Amanollah Zarei,Gorjizadeh, Maryam,Afshari, Mozhgan,Keshavarz, Mosadegh
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p. 733 - 739
(2015/10/28)
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- Synthesis and cytotoxicity of novel pyrazole derivatives derived from 3-Methyl-1-phenyl-1hpyrazol-5(4H)-one
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THE 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) was used to synthesis pyran,and pyridine derivatives through its multicomponent reactions with aromatic aldehydes and cyanomethylene reagents. The synthesized products were evaluated for their cytotoxicity ag
- El-Arab, Elham Ezz
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p. 741 - 753
(2016/08/19)
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- Uncapped SnO2 quantum dot catalyzed cascade assembling of four components: A rapid and green approach to the pyrano[2,3-c]pyrazole and spiro-2-oxindole derivatives
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A new uncapped SnO2 quantum dots (QDs) catalyzed strategy for the synthesis of substituted pyrano[2,3-c]pyrazole and spiro-2-oxindole derivatives has been developed via a multicomponent one pot approach in aqueous medium. The reactions can be p
- Paul, Sanjay,Pradhan, Koyel,Ghosh, Sirshendu,De,Das, Asish R.
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p. 6088 - 6099
(2015/03/30)
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- Novel silica sodium carbonate (SSC): Preparation, characterization and its first catalytic application to the synthesis of new dihydropyrano[2,3-c] pyrazoles
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In this study, a novel and highly efficient catalyst was produced from a reaction between silica chloride and sodium hydrogen carbonate. This novel catalyst was named silica sodium carbonate (SSC), and was characterized by FT-IR, XRD, XRF and TG-DT analys
- Eskandari, Khalil,Karami, Bahador,Khodabakhshi, Saeed
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p. 124 - 130
(2014/07/08)
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- An environmentally friendly synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives catalyzed by tungstate sulfuric acid
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An efficient three-component synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles via a reaction between 3-methyl-1-phenyl-2-pyrazolin-5-one, aromatic aldehydes and malononitrile using tungstate sulfuric acid as a cataly
- Farahi, Mahnaz,Karami, Bahador,Sedighimehr, Iman,Tanuraghaj, Hamideh Mohamadi
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p. 1580 - 1582
(2015/02/02)
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- Novel silica sodium carbonate (SSC): Preparation, characterization and its first catalytic application to the synthesis of new dihydropyrano[2,3-c]pyrazoles
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In this study, a novel and highly efficient catalyst was produced from a reaction between silica chloride and sodium hydrogen carbonate. This novel catalyst was named silica sodium carbonate (SSC), and was characterized by FT-IR, XRD, XRF and TG-DT analys
- Eskandari, Khalil,Karami, Bahador,Khodabakhshi, Saeed
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p. 124 - 130
(2015/03/18)
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